Gynecologic Flashcards
What tanner stage for women? Areola and nipple project as secondary mound
stage 4
What tanner stage for women? Preadolescent breasts
stage 1
What tanner stage for women? Breast enlargement without separate nipple contour
stage 3
What tanner stage for women? Breast buds with areolar enlargement
stage 2
What tanner stage for women? Areola recedes, nipple retracts
stage 5
Example of primary amenorrhea
Absence of menarche by age 16
Primary or secondary? Cessation of menstrual flow after the establishment of normal menstrual cycling
secondary
Absence of menarche, absence of secondary sex characteristics, abnormal growth and development
primary amenorrhea
Diagnosis test for amenorrhea
pregnancy test, refer to endocrinologist/obgyn, referral for other studies
Risk factors for cervical cancer
HPC (early, multiple sexual partners), male partner who has had multiple sexual partners, cigarette smoking, NOT HEREDITARY
BETHESDA classification system
- ASCUS
- Low-grade squamous intraepithelial lesion (LSIL or LGSIL)
a. Cervical intraepithelial neoplasia (CIN 1): HPV or mild dysplasia - High-grade squamous intraepithelial lesions (HSILor HGSIL)
a. CIN 2: moderate dysplasia
b. CIN 3: Severe dysplasia - Carcinoma in situ (CIS)
- Squamous cell carcinoma
Management if pap result is: infection
treatment based on causative agent; repeat PAP 3-4 months after treatment
Management of ASCUS
“watch and repeat”
HPV test, repeat PAP smear
Management of LSIL and up
Colposcopy. Refer if CIN 2,3, or CIS
Top Killers of adults in the US
- Heart disease
- Cancer
- Unintentional injury
- low respiratory disease
- CVA
Cancer in women: responsible for the highest mortality?
Lung
Cancer in women: leading GYN-associated cancer “killer”
Ovarian
Cancer in women: highest incidence other than skin cancer?
Breast
Cancer in men: highest mortality?
Lung
2nd most common cancer in men and #2 cancer killer?
Prostate
Men and women leading cancer killer?
Lung
Second leading cancer killer for men and women?
Colorectal
when do we stop screening for cervical cancer?
> 65 years (for patients with adequate negative prior screening and no history of CIN2 or higher within the last 25 years)
How often do we screen cytology for cervical cancer age 21-29?
cytology alone every 3 years. HPV test every 5 years preferred
Patients aged 30-65 years, how often can we do co-testing?
Q5 years is acceptable
Inflammation or infection of the vulva and vagina most commonly caused by bacteria, protozoa, and/or fungi
vulvovaginitis
Symptom of trichomoniasis in men:
often asymptomatic;
malodorous, frothy yellowish-green discharge
what infection? Strawberry patches on cervix and vagina
Trichomoniasis
What infection? watery, gra, “fishy” smelling discharge
Bacterial vaginosis
What infection? Frothy yellowish-green discharge, pruritus
Trichomoniasis
Vulvovaginal erythema with pruritus, thick white curd-like discharge
candidiasis
what infection? normal caline muxture shows irregularly-shaped vaginal epithelial cells (i.r. clue cells)
bacterial vaginosis
what infection? KOH mixture show pseudohyphae
Candidiasis
What infection? potassium hydroxide added to culture produces characteristic odor (i.e. whiff test)
bacterial vaginosis
what infection? motile trichomonads
trichomoniasis
Management of trichomoniasis (men and women)
Metronidazole (women 500 mg BID for 7 days; men 2 g single dose)
What should patients avoid when taking Metronidazole?
avoid drinking alcohol
Management of bacterial vaginosis
Metronidazole 500 mg BID for 7 days OR metronidazole gel 0.75% intravaginally once a day for 5 days OR clindamycin cream 2% intravaginally at bedtime for 7 days
Alternative: Tinidazole 2 grams orally once a day for 2 days OR tinidazole 1 gram orally once daily for 5 days OR CLindamycin 300 mg BID for 7 days OR clindamycin ovules 100 mg intravaginally once at bedtime for 3 days OR Secnidazole 2 grams orally in a single dose, taken with soft food
Management of candidiasis
OTC intraveginal agents: clotrimazole, miconazole or tioconazole intravaginally or as a vaginal suppository. Precription intravaginal agents: butoconazole or terconazole intravaginally or as a vaginal suppository
What are the symptoms of PID?
fever/chills, n/v, vaginal discharge, dysuria, dyspareunia, lower abdominal pain, INFERTILITY
What finding is positive cervical motion tenderness?
PID
What finding is adnexal tenderness, abdominal tenderness, fever >38 degress Celsius?
PID
Diagnostic tests for PID
STD testing, elevated ESR or C-reactive protein, ultrasound documentation of ovarian cyst
Management of PID
Ceftriaxone 500 mg IM in a single dose PLUS Doxycycline 100 mg orally twice a day for 14 days WITH metronidazole 500mg orally twice a day for 14 days
OR
Cefoxitin 2 g IM and probenecid 1 g orally administered together at once PLUS Doxycycline 100 mg orally twice a day for 14 days WITH metronidazole 500 mg orally twice a day for 14 days
Cramping pain occurring with menstruation
Dysmenorrhea
Primary dysmenorrhea
occurs in adolescent women as a result of high levels of prostaglandin (pain begins after onset of menses and no pelvic pathology is identified
Secondary dysmenorrhea
Occurs in women >20 years; more likely associated with some form of pelvic disease
Management of primary dysmenorrhea
- Prostaglandin synthetase inhibitors (start them on NSAID before periods start - ibuprofen, naproxen, indomethacin)
- Oral contraceptive pills
- Exercise
D. High fiber diet and reduction of sugar, caffeine and salt
Initial approach to vaginal bleeding
- evaluate for pregnancy
- Evaluate for uterine bleeding
a. non-uterine examples: cervix, vagina, urethra, anus
b. uterine bleeding indications: 1. coincident with bowel movement and wiping, occurs during or after urination and/or intercourse, is there vaginal, vulvar, perineal, or anal pain/irritation?
If not uterine: conduct pelvic exam
If uterine: determine using PALM-COEIN
What does PALM-COEIN stand for?
used for abnormal uterine bleeding
polyps, adenomyosis, leoimyoma, malignancy and hyperplasia, coagulopathy, ovulatory dysfunction, endometrial causes, iatrogenic causes, not yet classified
Diagnostic tests for abnormal uterine bleeding
hCG (quantitative), prolactin, TSH, CBC, PAP, STD screening, Urinalysis
Medical management for PMS/PDD
bromocriptine, alprazolam, buspirone, TCA, clomipamine HCL, SSRI,atenolol, oral contraceptive pills, and progesterone
Dietary management for PMS, PDD
caffeine restriction, vitamin E, salt restriction, vitamin B6, exercise
What is abnormal metabolism of androgens and estrogen; results in ovarian cysts?
Polycystic Ovary Syndrome
What is the most common cause of infertility in women?
PCOS
Management of PCOS
lifestyle changes (diet and exercise), oral contraceptives for menstrual regulation, insulin-sensitizing medication (metformin), hair removal treatment, and acne treatment
Management of fibrocystic breast disease
warm soaks TID, low sodium diet, vitamin supplements, hormonal therapy, surgical intervention
When to being breast cancer screening?
May begin by age 40
How often to do breast cancer screening?
every 2 years after age 50 to 74
When to end breast cancer screening?
After age 75, if they have quality of life for >10 years, encourage it…with shared decision making
Average age of menopause is?
51 years, range from 45 to 55 years
True or false: menopause can result in atherosclerosis, CAD, osteoporosis, and changes in skin pigmentation
true
True or false: menopause can result in recurring UTIs and urinary urgency
true
Management of menopause
- Estrogen therapy: provides most menopausal symptom relief for patients without a uterus due to a hysterectomy
- Estrogen plus progestogen therapy: for women with a uterus to protect against endometrial cancer from estrogen alone
- Encourage exercise, calcium supplementation, and health diet
- non-hormonal tx of vasomotor symptoms: paroxetine (SSRI), vaginal lubricants and low dose vaginal estrogen
Contraindications for hormone therapy (menopause)
- breast cancer
- endometrial cancer
- CAD/CHD (including hypertriglyceridemia)
- venous thromboembolic disorders
- active liver disease
- unexplained vaginal bleeding
- endometriosis and/or fibroids
Top 6 risk factors for osteoporosis
- female, white, or asian
- elderly
- early menopause
- estrogen deficiency
- small frame or underweight
- family history
What is normal DEXA score
T scores > -1.0 SD normal
what is osteoporosis DEXA score
below -2.5 is osteoporosis
What are some dietary sources of calcium?
dairy products, sardines, salmon with bones, green leafy vegetables, tofu, calcium fortified foods, take vitamin D (800-1000 IU/day)
supplements for osteoporosis
most common: calcium carbonate
shoult not be taken with high fiberfoods
avoid aluminum containing antacids
Drug therapies for osteoporosis
Estrogens, biphosphonates (alendronate, ibandronate, risedronate)
instructions for oral administration of biphosphonates
take with a full glass of water, NPO 30 minutes to 1 hour, sit upright 30 minutes to 1 hour
s/s fever, anorexia, weight loss, butterfly rash, periungual erythema, splinter hemorrhages, alopecia, joint symptoms
SLE
Laboratory/diagnostics for SLE
ANA + in 95% patients
antiphospholipid antibodies
anemia, leukopenia, and thrombocytopenia
management for SLE
- mild symptoms: bed rest, midafternoon naps, avoidanceof fatigue
- sun protection
- topical glucocorticoid for isolated skin lesion
- NSAIDs, hydroxychloroquine, glucocorticoids, and other therapies