Gynaecological oncology Flashcards
What are the two types of cervical cancer and what is their prognosis
- Squamous cell carcinoma - most common lower mortality
- Adenocarcinoma - rarer higher mortality
Cervical cancer: epidemiology
Epidemiology
- Commonest cancer in young women
- Disease of low resource country w/out screening
Two cell types on endo and ecto cervix
On the vagina side - ectocervix - squamous
On the utrerus side - endocervix - columnar (mucous prodcing ergo cancer her is known as adenocarcinoma)
Cervical cancer: aetiology
Aetiology
Oncogenic HPV w/ smoking as co-factor –> premalignant disease–>ca over years
Cervical cancer: risk factors
Risk factors
Smoking
Having children
Immunosuppression
HPV
Herpes/STIs
OCD/IUD
Exposure to DES (abortion drug)
Young age
Cervical cancer: sx
Sx
Irregular periods (IMB)
Post coital bleeding
Smelly vaginal discharge from the surface of the tumour
Late stage – malignant pain and fistula
Cervical cancer: clinical assessment
Clinical assessment
Mass felt of seen on cervix
Screening detecting (subclinical)
Cervical cancer diagnosis
Diagnosis
Colposcopy and biopsy of lesion
MRI to assess for invasion
Cervical cancer: prognosis.
Prognosis
Good if picked up early
Poor if locally advanced
Good life quality if in remission, but late effects of radiotherapy might be an issue
Cervical cancer:management
Management
Loop diathermy (microscopic disease)
Hysterectomy w/ node removal (macroscopic disease)
May also have chemo radiotherapy
Cervical screening: frequency
- Cervical screening offered to all women aged 25-49 every 3 years and 50-64 every 5 years
- Screening involves a smear from the surface of the cervix via a speculum
- If the cells are found to be abnormal the follow up is colposcopy
Endometrial cancer: epidemiology
Epidemiology
- Commonest gynae cancer
- Disease of affluent west
Endometrial cancer: aetiology
Aetiology
Disease of the menopause
Type one (low grade) – related to obesity and PCOS (polycystic ovary syndrome)
Type two (high grade) – genetic mutations?
Endometrial cancer: sx
Sx
Post menopausal bleeding/discharge (1 year after last period)
Endometrial cancer: clinial assessment
Clinical assessment
Often nothing to find as at early stage