Antenatal Care Flashcards
Common modes of inheritance
Autosomal D/r
X-linked D/r
Codominant
Mitochondrial
3 commonest severe congenital abnormalities
Heart Defects
Neural Tube Defects
Downs
4 General considerations for perscribing in pregnancy
1) Pre-pregnancy counselling optimises medication
2) Balance risk to fetus with benefit to mother
3) Assess on individual basis, give information so that an informed decision can be made
4) LOWEST POSSIBLE DOSE FOR SHORTEST TIME POSSIBLE
3 Physiological changes in pregnancy relevant to perscribing
Affects distribution
1) Increase in total body water
2) Increase in fat stores
Affects metabolism
1)Increaase in cardiac output
Pharmokinetic changes in pregnancy
Absorption
- Dec due to n & v (nausea + vomiting)
Distribution
- Inc plasma volume
- Dec plasma binding
Metabolism
- Cyt P450 induction
- Increase eGFR
Elimination
- No change
Generally dec drug conc due to haemodilution, inc distridution + metabolism
Teratogenic drugs in pregnancy
Thalidomide
Diethylstilboestrol (used in breast and prostate cancer and recurrent miscarriage)
Warfrin
Phenytoin
Lithium
Methotrexate
Testosterone
Progesterone
Valproate
Benzodiazopine
Most anti-psychotics except: quetiapine, olanzapine, or risperidone
All AED except (Lamotrogine + levetricetam)
Time line of antenatal screening
What happens at a booking appointment
First contact with midwife
- Information gathered
- General info taken (name, age gestation)
- Risk assessed (obs hx, drug use, domestic abuse, PMH, )
- Baseline obs taken - BP, temp, weight
- Bloods taken - Hb, iron, rhesus, blood group, downs, spina bifida, HIV, syphillis, thalasaemia, Hep B,
- Urine dip
- Information given
- Pregnancy plan initiated
Standard antenatal screening offered to women
8-12 weeks - Bloods for infectious disease Syphilis, Hep B + HIV (usually done at booking apt)
>10 weeks - Bloods for Sickle and Thalesaemia (usually done at booking apt)
10 weeks - Booking appointment
10-14 weeks - Combined test Bloods for T21 (downs), T18 (edwards) and T13 (Pataus)
11-14 weeks - Dating scan and early anomoly scan (the same scan aka Nuchal Translucency), supports combined test and looks for other defects
14-20 weeks - Quadruple test Bloods for T21 and spina bifida (not offered to everyone)
18-21 weeks - Anomoly scan detailed USS for structural abnormalities incl T18 T21, supports quadruple bloods
Main reasons to be CLC
- <16/>40 years
- Grand multip >6
- >35 BMI
- Won’t take blood products
- Cervial suture/LLETZ
- HTN
- Familial genetic abnormalities
- Drug user
- Alcoholic
- STI e.g. herpes
- If only risk is smoking MLC, but need serial growth scans in 3rd trimester
- Pre-eclampsia
- Gestational diabetes
- Shoulder distocia
- 3/4th degree tear
- Previous C section
- Epilepsy
- Multiple pregnancy
- Antepartum haemorrhage
- Recurrent UTI
full list at: https://www.nuh.nhs.uk/handlers/downloads.ashx?id=62572
Aim of screening
Monitor normal pregnancy
Identify complicated pregnancy
Identify risks and requirements of mother and fetus
Risks of and management of VBAC
Risks
- 0.5% scar dehiscence
- Think about future pregnancies, no more than 3 c-sections recommended + risk of placenta accreta
- Emergency c-section
Management
- CLC
- Counsell for risks before (70% successfull)
- Should be done in hospital access to c-section
- Pain between contractions can indicate rupture
- Continuous CTG
- Maternal pulse changes can indicate rupture
- Check for bleeding can indicate rupture
- Induction caries 1.5 increase risk of rupture
Risks of and management of Group B strep infection
Risks (fetal)
- Septicaemia
- Pneumonia
- Meningitis
Management
- Intrapartum antibiotic prophylaxis (IAP)
- If in urine given treatment at time of diagnosis not indicated for vaginal/rectal
- IAP not needed in c-section if membranes have not ruptured
- Once membranes ruptured induction is recommended at 37w
Risks of, risks for and management of breech
Risks for
- High parity
- Uterine/pelvic abnormalities
- Previous breech
- Placenta abnormalities
- Fetal abnormalities
- Multiple pregnancy
- Low birth weight/pre-term
- Polyhydramnious
- Space occupying lesion
Risks of
- Cord Prolapse
- Hypoxia to baby
- Head entrapment
Managment
- Counsell mother with risks + create a birth plan
- Terms breech trial says planned c-section has better outcomes, recent studies conflict. Green top says women should be told c-section has small decrease in perinatal mortality but vaginal is better for mum + normal counselling for c-section and vaginal birth Re-read green top http://onlinelibrary.wiley.com/doi/10.1111/1471-0528.14465/full
- ECV (check contraindications)
- Labour in hospital access to c-section
- Induction not recommended
- Continuous CTG
- Consider c-section if descent is delayed in 2nd stage of labour
- If 2nd twin = breech can do total breech extraction
Types of breech, best and worst
- Frank/extended breech- crossed legs next to ears
- Complete breech-crossed legs above buttock
- Footling breech-presenting part is foot WORST