GYN Flashcards
The diagnosis of congenital adrenal hyperplasia is made by elevated _______________ or urine 17-ketosteroid with decreased serum cortisol.
17α-hydroxyprogesterone
______________ is an infrequently occurring chronic pruritic papular eruption that localizes to areas, where apocrine glands are found.
Fox-Fordyce disease
_________________ is a skin disease that most commonly affects areas bearing apocrine sweat glands or sebaceous glands, such as the underarms, breasts, inner thighs, groin, and buttocks.
Hidradenitis suppurativa
- Initial treatment for hidradenitis includes antimicrobial skin washes and antibiotic ointments.
The ______________ are located bilaterally at approximately 4-o’clock and 8-o’clock positions on the posterior–lateral aspect of the vaginal orifice
Bartholin’s glands
When a Bartholin’s duct cyst first presents in a woman older than _________ , a biopsy should be performed to rule out the rare possibility of Bartholin’s gland carcinoma.
40 years
______________ is usually done for recurrent Bartholin’s duct cysts or abscesses. The entire abscess or cyst is incised, and the cyst wall is sutured to the vaginal mucosa to prevent reformation of the abscess
Marsupialization
_______________ are remnants of the mesonephric ducts of the Wolffian system. They are found most commonly in the anterior lateral aspects of the upper part of the vagina.
Gartner’s duct cysts
______________ are elevated soft red papules, also known as Campbell De Morgan spots or senile angiomas; they contain an abnormal proliferation of blood vessels.
Cherry hemangiomas
________________ and urethral prolapse present as small, red, fleshy tumors found at the distal urethral meatus. These occur almost exclusively in postmenopausal women as a result of genital urinary syndrome of menopause.
Urethral caruncles
Women who have been exposed to DES in utero are also at increased risk of a very rare ________________ of the cervix and vagina.
clear cell adenocarcinoma
Most cervical cysts are mucus-filled retention cysts called _______________. These are caused by intermittent blockage of an endocervical gland and usually expand to no more than 1 cm in diameter.
nabothian cysts
When symptomatic, ______________ usually cause intermenstrual or postcoital spotting rather than pain.
cervical polyps
_______________ are common benign tumors of the uterine corpus but may also arise in the cervix or prolapse into the cervical or vaginal canal from the endometrial cavity.
Leiomyomas (myomas or fibroids)
The ___________ can be identified as small openings on either side and just below the urethral meatus.
Skene’s glands
___________ is a chronic and progress benign condition characterized by vulvar inflammation and epithelial thinning. Symptoms include intense pruritus, pain, and anogenital hypopigmentation (whitening—often in a “keyhole” fashion around the perineum and anal region). When left untreated, it can result in distortion of vulvar architecture (loss of labia minora, constriction of the introitus, fissures, labial fusion, and scarring).
Lichen sclerosis
_____________, also called fibroids or uterine myomas, are benign proliferations of smooth muscle cells of the myometrium.
Uterine leiomyomas
The typical classification includes submucosal (beneath the endometrium), intramural (in the muscular wall of the uterus), and subserosal (beneath the uterine serosa). _______________ are the most common type, and ________________ are commonly associated with heavy or prolonged bleeding.
Intramural leiomyomas; submucosal fibroids
Most women with fibroids (50% to 65%) have no clinical symptoms. Of those who do, ______________ is by far the most common symptom.
abnormal uterine bleeding
Bimanual examination often reveals a nontender irregularly enlarged uterus with “lumpy-bumpy” or cobblestone protrusions that feel firm or solid on palpation.
Uterine leiomyomas
Other pelvic masses should be ruled out, and the patient with actively growing fibroids should be followed every ____ months to monitor the size and growth.
6
____________ is the definitive treatment for leiomyomas.
Hysterectomy
Women taking ____________ for breast cancer prevention are at risk of developing endometrial polyps, cysts, and cancer.
Tamoxifen
Endometrial polyps account for a quarter of all causes of ______________.
postmenopausal bleeding
Endometrial proliferation is a normal part of the menstrual cycle that occurs during the follicular (_______________) estrogen-dominant phase of the cycle.
proliferative
______________ are the most common functional cysts.
Follicular cysts
Follicular cysts are the most common functional cysts. They arise after failure of a follicle to rupture during the ____________________ of the menstrual cycle.
follicular maturation phase
- Functional cysts may vary in size from 3 to 8 cm and are classically asymptomatic and usually unilateral.
Corpus luteum cysts are common functional cysts that occur during the _______________ of the menstrual cycle.
luteal phase
- These cysts can cause a delay in menstruation and dull lower quadrant pain. Patients with a ruptured corpus luteum cyst can present with acute pain and signs of hemoperitoneum late in the luteal phase.
________________ are large bilateral cysts filled with clear, straw-colored fluid. These ovarian cysts result from stimulation by abnormally high β- human chorionic gonadotropin
Theca lutein cysts
These cysts are also called “chocolate cysts,” which comes from the thick brown old blood contained in them. Patients can present with the symptoms of endometriosis such as pelvic pain, dysmenorrhea, dyspareunia, and infertility.
Endometriomas
More than 75% of ovarian masses in women of reproductive age are ___________ and less than 25% are ________________.
functional cysts; nonfunctional neoplasms
The primary imaging tool for the workup for cystic adnexal masses is the _________________.
Transvaginal pelvic ultrasound
A _________ level is often obtained from patients who are at high risk for ovarian cancer.
CA-125
_______________ is a chronic disease marked by the presence of endometrial tissue (glands and stroma) outside the endometrial cavity.
Endometriosis
Endometriosis in the ovary commonly appears as a cystic collection known as an ________________.
endometrioma
The ______________ proposes that endometrial tissue is transported via the lymphatic system to various sites in the pelvis, where it grows ectopically.
Halban theory
__________ proposes that multipotential cells in peritoneal tissue undergo metaplastic transformation into functional endometrial tissue.
Meyer
____________ suggests that endometrial tissue is transported through the fallopian tubes during retrograde menstruation, resulting in intra-abdominal pelvic implants.
Sampson
The hallmark of endometriosis is _____________ before menses, peaking 1 to 2 days before the onset of menses, and subsiding at the onset of menses or shortly thereafter.
cyclic pelvic beginning
When the clinical impression and initial evaluation are consistent with endometriosis, ________________ is often favored over surgical intervention as a safe approach to management.
empiric medical therapy
However, the only way to definitively diagnose endometriosis is through __________________.
direct visualization with laparoscopy or laparotomy
______________ is recommended for histologic confirmation of the diagnosis of endometriosis.
Peritoneal biopsy
_____________ is the presence of endometrial tissue (glands and stroma) WITHIN the myometrium
Adenomyosis
One theory proposes that the endometrium directly invades the myometrium.
Adenomyosis
The adenomyotic changes are usually most extensive in the ___________ and ____________.
fundus and posterior uterine wall
Adenomyosis may also present as a well-circumscribed, isolated region known as an _______________.
adenomyoma
Unlike uterine fibroids, which have a characteristic pseudocapsule, individual areas of adenomyosis are ____________.
not encapsulated
The presence of endometrial tissue in the uterine myometrium leading to abnormal bleeding and pain. The uterus becomes soft and globular.
Adenomyosis
_____________ and ____________ is the most effective treatment for adenomyosis.
Progestin-containing IUD or hysterectomy
A well-circumscribed collection of endometrial tissue within the uterine wall. They may also contain smooth muscle cells and are not encapsulated.
Adenomyoma
The presence of endometrial cells outside the uterine cavity. The hallmark of this chronic disease is cyclic pelvic pain.
Endometriosis
A cystic collection of endometrial cells, old blood, and menstrual debris on the ovary; also known as “chocolate cysts.”
Endometrioma
Local proliferations of smooth muscle cells within the myometrium, often surrounded by a pseudocapsule. Also known as fibroids, these benign growths may be located on the intramural, subserosal, or submucosal portions of the uterus.
Leiomyoma
The pelvic examination of a patient with adenomyosis may reveal a ____________________. The uterus is usually less than _____ cm.
diffusely enlarged globular uterus; 14 cm
The consistency of the uterus is typically softer and boggier than the firmer, rubbery uterus containing fibroids.
Adenomyosis
Prior to treating adenomyosis, any patient aged 45 years or older with change in menstrual quantity or pattern should have a _______________, ______________, and ______________ to rule out other causes of abnormal uterine bleeding.
- Thyroid stimulating hormone (TSH)
- Pelvic ultrasound
- Endometrial biopsy
______ is the most accurate imaging tool for identifying adenomyosis.
MRI
However, because the cost of MRI can be prohibitive, ____________ is the most common imaging modality.
pelvic ultrasound
Ultimately, ____________ is the only definitive means of diagnosing adenomyosis.
hysterectomy
The _______________ has been found to be the most effective temporary means of managing the symptoms of adenomyosis
levonorgestrel-containing intrauterine device (IUD)
Genetic factors probably are associated with the risk of developing endometriosis, and an increased risk of developing endometriosis has been observed in ______-degree relatives.
First
_____________ is typically used to screen for intracavitary lesions, such as endometrial polyps or submucosal fibroids.
Sonohysterography
The most common cause of vulvitis, and usually of vulvar pruritus, is ____________.
candidiasis