Guillian-barre syndrome Flashcards
define guillain barre syndrome?
immune mediated demyelination of the peripheral nervous system often triggered by an infection.
what is the main viral agent causing guillain barre syndrome
Campylobacter jejuni
typical ages to get guillain barre syndrome?
15-35 and 50-75
initial symptoms of guillain barre syndrome?
around 65% of patients experience back/ leg pain
characteristic symptoms of guillain barre syndrome?
- progressive, symmetrical weakness of all the limbs beginning in the legs
- Reflexes are absent/reduced
- Distal paraesthesia
- History of gastroenteritis
what are the features of miller fisher variant?
ophthalmoplegia, ataxia, arreflexia
what are the motor signs of guillain barre syndrome?
o Hypotonia
o Flaccid paralysis
o Arreflexia
o Due to paralysis of respiratory muscles
what are the sensory signs of guillain barre syndrome?
o Progressive parasthesia
what are the cranial nerve signs of guillain barre syndrome?
o Diplopia
o Bilateral facial nerve palsy
o Oropharyngeal weakness is common
what are the autonomic signs of guillain barre syndrome?
o Urinary retention
o Diarrhoea
what investigations should be undertaken for guillain barre syndrome?
• Lumbar Puncture
o HIGH protein
o NORMAL white cell count and glucose
• Nerve Conduction Study
o Reduced motor nerve conduction velocity
o Prolonged distal motor latency
o Increased F wave latency
what antibodies might be present on bloods for guillain barre syndrome?
o Anti-ganglioside antibodies
