GU/renal Flashcards
pathophys of rhabdo
from destruction of skeletal muscle due to injury of myocytes
common causes of rhabdo
drugs of abuse (cocaine, meth), alcohol (direct toxic effect and coma induced muscle breakdown aka passing otu no muscle), medications (antipsychotics, statins, SSRI, huge list), muscle diseases, trauma, NMS, seizures, immobility, infection, strenous physical activity, heat-illness.
** more than 1/2 the time there are multiple causes present
rhabdo symptoms
weakness, myalgias, malaise, dark brown urine (tea colored urine)
if severe can lead to n/v, abdo pain or even urea induced encephalopathy
rhabdo cutoffs for dx, IVF and trend, vs admit
> 1000 is dx
5000 probable admit
dialysis indications in rhabdo?
same as any other pt… AEIOU
treatment of rhabdo
aggressive IV fluid (Ns or RL), for 24 to 72 hours. target OU of 200 mL per hour or 3 mL/kg/hr.
basically, boluses then 250-500 mL per hour based on pt factors (age, EF etc)
4 general complications of rhabdo
AKI, DIC, electrolyte abn (K, P, Ca), mechanical complications (compartment syndrome, peripheral neuropathy)
uremic symptoms
n/v, drowsiness, fatigue, confusion, if untreated coma
fastest screening test for hyperK?
ECG
detects 50% of levels over 6.5
creatinine changes required for AKI
Cr increase of 26, over less then 48 hrs
ACE inhibitor effects on kindeys
decrease GFR, but also decrease glomerular pressure
preferentially vasodilate efferent arteriole
NSAIDs effect on kidney arterioles
vasoconstrict afferent
general treatment principles in AKI
target euvolemia, hold insulting meds, relieve/rule out obstruction (u/s and foley)
look for hyper K, metabolic acidosis (WAGMA), proteinuria etc.
indications for acute dialysis
A: refractory/life threatening acidosis
E: refractory hyper K (>6.5 and not improving)
I: life-threatening ingestion of dialyzable drug (common methanol/ethylene glycol, salicylates, lithium)
O: refractory overload (causing hypoxia)
U: symptomatic uremia (pericarditis, encephalopathy, bleeding)
hyperkalemic ECG
peaked T waves, prolonged PR, wide QRS and then sinusoidal pattern
broad definition of cardiorenal syndrome
acute or chronic dysfunction of one organ causes acute or chronic dysfunction of the other
metformin and contrast CT
if gfr >30 and on metformin go for it, otherwise hold metformin for 48 hrs before and after (if possible)
define uremia
a (poorly named) clinical syndrome, involves accumulation of urea AND OTHER metabolites in the blood which cause sequalae that are not solely resolved by dialyzing them out, it is the end-point of CKD/ESRD…. interestingly BUN is inaccurate marker of uremia severity
uremic neurologic complications (3):
uremic encephalopathy, dialysis dementia, peripheral neuropathy
cardiovascular complications of uremia
elevated troponins, HTN, HF, uremic cardiomyopathy, pulm edema, tamponade, pericarditis, CAD
unique feature of uremic pericarditis?
aseptic and inflammatory cells dont enter myocardium, so you dont get the ECG changes!
hematologic complications of uremia? 3
anemia, coagulopathy, immune disorders
do you remove dialysis line if infected?
generally trial IV abx for 2-3 days first.
what is Branham sign?
indicates high out put HF/AV fistula steal syndrome, you occlude fistula and look for drop in HR.
complications during dialysis (4)
hypotension (often due to volume loss), dialysis dysequilibrium (due to osmolar changes, s/s are n/v and HTN, can be life threatneing), air embolism, electrolyte abn
most common organisms in PD peritonitis?
staph and strep, gram neg can occur too
signs/symptoms of PD peritonitis
fever, abdo pain, guarding, peritonitic signs
size of catheter in acute urinary retention
14-16F
what is coude tip catherter?
has angled and firm tip, which should be angled anterioirly to follow the anatomy