gu: MOA

Question 1

a-1 blockers MOA

Answer 1

prevents activation of a-1 receptors > relaxation of smooth muscle > vasodilation and decr tone of bladder and prostate

Question 2

5-a reductase inhib MOA

Answer 2

• 5-a reductase converts testo to dihydrotesto (DHT) in prostate and hair follicles
• DHT more potent hormone, asso w/enlarge prostate
• inhib 5-a reductase- lower DHT levels and indirectly reduces size of prostate

Question 3

PDE5 inhib MOA

Answer 3

-NO stimulates the production of cGMP
in penile tissue
-cGMP causes smooth muscle relaxation, incr blood
flow for erection
-PDE5 degrades cGMP
-Inhib of PDE5 incr cGMP levels

Question 4

anticholinergics MOA

Answer 4

-ACh binds to muscarinic
receptors > contraction of
smooth muscle (detrusor muscle) > urine release
-antichol decr action of ACh at muscarinic receptors in the bladder

Question 5

Phenazopyridine MOA

Answer 5

• unknown

- Azo dye that provides localized analgesic effect on the urinary tract mucosa