Growth and Growth Disorders Flashcards

1
Q

You are half your height by what age

A

2 yrs

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2
Q

Short stature is defined as

A

-2 Standard Deviations (or less than 2.3% below the mean)

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3
Q

Primary ENDOCRINE cause of short stature

A

Hypothyroidism

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4
Q

If a girl has short stature, what condition might a pediatrician evaluate her for?

A

Turner’s syndrome

*do chromosome analysis

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5
Q

When can you give a child growth hormone?

A
  • low birth wt
  • didn’t meet catch up height
  • (one more)
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6
Q

Primary causes of growth delay

A

Skeletal
chromosomal
IUGR

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7
Q

Secondary causes of growth delay

A
Malnutrition
GI
Renal
Cardiac
Endocrine
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8
Q

What is layman’s term for constitutional delay?

A

Late Bloomer

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9
Q

If you see a growth chart with wt going up and ht going down think

A

Cortisol Excess

  • Cushing’s
  • rare
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10
Q

Most common cause of acquired Growth Hormone deficiency

A

Cranialpharygeoma

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11
Q

Side Effect of IGF-1?

A

Hypoglycemia

acts as insulin stimulator? or replacement

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12
Q

Regimen for GH Tx

A

Daily

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13
Q

When can a child take GH?

A

Less than 1% of normal on growth chart

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14
Q
  • Hall mark feature: Normal bone age?

concordant bone age

A

Familial Short Stature

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15
Q

*Hall mark feature: Delayed bone age

A

Constitutional Growth Delay

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16
Q

*Most common cause of congenital hypervirlization in females

A

See slide 69 FIX

P-450 deficiency
c21 (21 hydroxylase?)

17
Q

What is elevated in CAH?

A

17-OH progesterone

18
Q

What gene is blocked in CAH

A

21 hydroxylase gene

19
Q

Tall stature is defined as

A

+2 Standard Deviations above the mean

>97.7%

20
Q

Male Predicted Ht

A

(M+5) +D/2

*inches (+/-2)

21
Q

Female Predicted Ht

A

M + (D-5)/2

*inches (+/-2)

22
Q

What should you do if you suspect a growth deficiency?

A

Get MRI of the brain to be sure it’s not pituitary problem