Growth and Growth Disorders Flashcards
You are half your height by what age
2 yrs
Short stature is defined as
-2 Standard Deviations (or less than 2.3% below the mean)
Primary ENDOCRINE cause of short stature
Hypothyroidism
If a girl has short stature, what condition might a pediatrician evaluate her for?
Turner’s syndrome
*do chromosome analysis
When can you give a child growth hormone?
- low birth wt
- didn’t meet catch up height
- (one more)
Primary causes of growth delay
Skeletal
chromosomal
IUGR
Secondary causes of growth delay
Malnutrition GI Renal Cardiac Endocrine
What is layman’s term for constitutional delay?
Late Bloomer
If you see a growth chart with wt going up and ht going down think
Cortisol Excess
- Cushing’s
- rare
Most common cause of acquired Growth Hormone deficiency
Cranialpharygeoma
Side Effect of IGF-1?
Hypoglycemia
acts as insulin stimulator? or replacement
Regimen for GH Tx
Daily
When can a child take GH?
Less than 1% of normal on growth chart
- Hall mark feature: Normal bone age?
concordant bone age
Familial Short Stature
*Hall mark feature: Delayed bone age
Constitutional Growth Delay
*Most common cause of congenital hypervirlization in females
See slide 69 FIX
P-450 deficiency
c21 (21 hydroxylase?)
What is elevated in CAH?
17-OH progesterone
What gene is blocked in CAH
21 hydroxylase gene
Tall stature is defined as
+2 Standard Deviations above the mean
>97.7%
Male Predicted Ht
(M+5) +D/2
*inches (+/-2)
Female Predicted Ht
M + (D-5)/2
*inches (+/-2)
What should you do if you suspect a growth deficiency?
Get MRI of the brain to be sure it’s not pituitary problem
