Gram (-) Rods/Bacilli Flashcards
aerobe (non-fermenting) oxidase + catalase + pyocyanin, fruit like odor capsule, exotoxin, endotoxin ubiquitously found in H20
P. aeruginosa
burn patients hot tub folliculitis Cystic fibrosis pts at risk Ecthyma gangrosum (black center, erythematous margin) chronic granulomatous disease
P. aeruginosa
because infxn w/ P. aeruginosa looks similar to enteric bacterial infxn, what is used to distinguish?
oxidase test
P. aeruginosa is oxidase +
enteric bacteria are oxidase -
mechanism of action of exotoxin of P. aeruginosa
inhibits protein synthesis vis eEF-2
similar to diptheria
transmission via aerosol droplets from contaminated air conditioning system
Legionella pneumophila
weakly gram (-) charcoal yeast extract agar (cysteine & iron) silver stain + facultative intracellular
Legionella pneumophilia
pontiac fever is cause by what bacteria
Legionella pneumophilia
Legionnaires disease is seem in what population of pts
smokers/drinkers/ >55 years/ immunocompromised
dx of legeionella
direct fluorescent antibody
no gram stain bc it stains weak
4x increase in ab
tx of legionella
abx that penetrates human cells
floroquinolones, erythromycin, azithromycin
add rifampin if immunocompromised
Gram - rod facultative intracellular zoonotic potential biowarfare tick bite --> rabbit---> human
Fancisella tularensis
gram - rod aerobe capsule reservoir- vaccinated human Mucosal surface pathogen Regan-Lowe media VACCINE
Bordetella pertussis
MOA pertussis toxin
ribosylation of Gi–> inc. AC–> inc. cAMP
hypoglycemia
block immune effector cells
increase histamine sensitivity
best stage to culture pertussis
catarrhal stage
“Cold” like illness
stage whooping cough shows up
paroxysmal stage