Gram -ive bacteria , Part 1

Question 1

Moraxella arranged in pairs (diplococci)
✔️or✖️

Answer 1

✖️

Neisseria

Question 2

( contains cytochrome oxidase enzyme)

Answer 2

Neisseria (Cocci - bacteria)

Question 3

Gram -ive Bacteria characterized by Petechical or purpuric rashes …….that caused by ……

Answer 3

Meningococcal septicemia
that is caused by Neisseria meningitidis

Question 4

Produces pyocyanin (a Blue-green pigment)

Nutritional requirements are minimum

causes many nosocomial infections

Answer 4

Pseudomonas aeruginosa
(Rod straight +O2 bacteria)

Question 5

Is common cause of otitis media in infants and children

produce beta lactamase,

Answer 5

Moraxella catarrhalis (Cocci -ive bacteria)

Question 6

Hyperproduction of endotoxin causes diffuse vascular damage

Ex. endothelial damage, thrombosis (clotting), disseminated intravascular coagulation (DIC)

Is P athogenesis of

Answer 6

meningococcal disease (Neisseria meningitidis)

Question 7

Penicillin no longer drug of choice for Neisseria gonorrhoeae due to:
• Plasmid-encoded beta-lactamase production
• Chromosomally-mediated resistance
✔️or✖️

Answer 7

✔️

Question 8

Produces DNAase,

Answer 8

Moraxella catarrhails

Question 9

Many enzymes like catalases, proteases, elastase and others two enzymes phospholipase
C and glycolipids help in local invasion of

Answer 9

Pseudomonas aeruginosa

Question 10

Release :
Endotoxins \ which produce fever and septic shock.

Exotoxin-A \ inactivates the EF-2

Answer 10

Pseudomonas aeruginosa

Question 11

Commonly colonize nasopharynx of health

Second most common cause (after S. pneumoniae) of community-acquired meningitis

Answer 11

Neisseria meningitidis

Question 12

Aminoglycosides and extended spectrum Penicillins are therapy for ….

Answer 12

Pseudomonas aeruginosa

Question 13

Post meningococcal reactive diseases lasting 15-20 days .

Answer 13

✖️

lasting 4-10 days

Question 14

What are the Post meningococcal reactive diseases

Answer 14

arthritis ,pericarditis , rash , fever

Question 15

Treatment for dual infections : Chlamydia + Neisseria gonorrhoea

Answer 15

ceftriaxone, cefixime or fluoroquinolone

Combined with

doxycycline or azithromycin

Question 16

capsule is the major virulence factor of

Answer 16

Neisseria meningitidis

Question 17

-Sensitive to dehydration
-has Kidney shaped

Answer 17

Neisseria gonorrhoeae

Question 18

More common in homosexual/bisexual men than in
heterosexual population

Source : asymptomatic in Females

usually occurs in combination with Syphilis, HIV or Trachoma.

Answer 18

Neisseria gonorrhoeae

Question 19

What are clinical significance of Pseudomonas aeruginosa

Answer 19

Pneumonia

Sepsis

External Otitis

UTI

Diabetic Osteomyelitis

Question 20

Ophthalmia neonatorum, pharangitis
Clinical significance of

Answer 20

Neisseria gonorrhoeae

Question 21

virulent factors of aerobic Neisseria

Answer 21

1- Pili (resistance to phagocytosis)

2- Outer membrane proteins
( OMP I + OMP III ) work in association as transporters ,, OMP II responsible for repeated infection and helps in attachment with pili together to epithelial cells of urethra , rectum and other mucosal cells

3- IgA protease ( produced by both gonococci and meningococcal ) work on cleaving IgA to help the pathogens evade

(evade = يتملص ، يتهرب)

4- Lipoologosacharides (LOS) -shorter , highly branched, non repeat O-antigen side chain as LPS.

Question 22

LOS antigen induces IgM in normal human serum
✔️or✖️

Answer 22

✔️