Graft Vs Host Disease Flashcards
1
Q
complication of
A
allogeinic stem cell transplantation
2
Q
what
A
T cells in donor tissue mount an immune response against recipient cells
3
Q
conditions required
A
- transplant contains functioning immune cells
- recipient and donor immunologically different
- recipient is immunocompromised
4
Q
Acute GvHD
A
<100 days transplant
affects skin, liver, GIT
5
Q
chronic GvHD
A
> 100 days
may occur following acute disease or de novo
often lung and eye involvement
6
Q
features of acute GvHD
A
painful maculopapular rash
jaundice
watery/bloody diarrhoea
N&V
7
Q
features of chronic GvHD
A
skin:scleroderma, vitiligo, lichen plannus
Eye: scleritis, corneal ulcers
GI: dysphagia, ulcers, ilues
lung disease
8
Q
Mx
A
mainstay is IV steroids
