B cell and immunoglobulin deficiency

Question 1

clinicall leads to

Answer 1

susceptibility to recurrent infections, esp LRTIs

Question 2

selective immunoglobulin A deficiency

Answer 2

low IgA
normal IgG and IgM

mild immunodeficiency
tendency to recurrent mucous membrane infections and autoimmune conditions

Question 3

common variable immunodeficiency

Answer 3

low IgF and IgA
+/- deficient in IgM

genetic mutation in genes coding for B cells

Question 4

common variable immunodeficiency - leads to

Answer 4

recurrent RTIs, leading to chronic lung disease

unable to develop immunity to infection or vaccination

prone to immune disorders, and cancers e.g. NH-lymphoma

Question 5

common variable immunodeficiency Mx

Answer 5

regular immunoglobulin infusions

treat infections and complications as they occur

Question 6

X linked agammaglobulinaemia

Answer 6

abnormal B cell development
deficiency in classes of immunoglobulins

causes similar issued to CVID

Question 7

X linked agammaglobulinaemia - inheritence pattern

Answer 7

x-linked recessive condition