complement disorders Flashcards
1
Q
complement proteins and most important in dealing with…
A
encapsulated organisms
- H influenza B
- strep pneumonia
- N meningitidis
2
Q
most common complement deficiency
A
C2 deficiency
3
Q
vaccination against X is important for patient with complement deficiencies
A
encapsulated organisms
4
Q
C1 Esterase Inhibitor Deficiency (Hereditary Angioedema)
A
C1 esterase inhibits bradykinin
An absence of C1 esterase causes intermittent angioedema in response to minor triggers
5
Q
bradykinin
A
part of inflammatory response
promotes blood vessel dilatation
increases vascular permeability
–> angioedema
6
Q
C1 Esterase Inhibitor Deficiency (Hereditary Angioedema)
- Mx
A
IV C1 esterase inhibitor
- prophylaxis prior to dental/surgical procedures
- in response to acute attacks
7
Q
C1 Esterase Inhibitor Deficiency (Hereditary Angioedema)
- key test
A
check C4 levels - will be low
