GP🧑🏽⚕️ Flashcards
What is stage one hypertension?
Over 140/90
What is stage two hypertension?
Over 160/100
What is Severe hypertension?
> 180 systolic >100 diastolic
What is accelerated hypertension?
Hypertension with associated severe papilloedema and retinal haemorrhage
What blood tests can you do in primary care for hypertension?
HbA1c, U&Es, lipid profile
What antihypertensive would you start in an over 55?
Calcium channel blocker
What investigations can you do in primary care for COPD?
- A CXR to exclude other pathologies
- FBC to identify anaemia or polycythaemia
- Sputum culture
- Social home peak flow measurements
- ECG and serum BNP
- ECHO
What might cause hypertension?
Essential/primary hypertension
Secondary Hypertension
- Cushing’s Disease
- Conn’s Syndrome
- Renal artery stenosis
- Coarctation of the aorta
- Pheochromocytoma
- Renal disease (PKD, Glomerulonephritis)
What are some non-modifiable risk factors for HTN?
Older age, FHx, Ethnicity Female
What are some modifiable factors for HTN?
Overweight, high salt intake, lack of activity, excess alcohol, stress
What investigation might you do for HTN in primary care?
End organ damage
- 12 lead ECG +/- echo
- U+E and eFR and urine drip
- Renal USS
CVD risk
- Blood glucose
- Fasting lipids
Secondary causes
- 24 hours urinary metanephrines
- Dexamethasone suppression
- Renin/Aldosterone ratio
How do you diagnose diabetes?
Random blood glucose - >11 mmol/L
Fasting blood glucose - >7 mmol/L
Glucose tolerance test - >11.1 mmol/L at 2 hour
Hba1c – 48 mmol/mol (6.5%)
What lifestyle advice do you give for a patient with T2DM?
- Healthy diet - low fat and sugar
- Increase exercise
- Smoking cessation
- Trial for 3 months then drug treatment
Risk factors for COPD?
- Tobacco smoking
- Occupational exposure
- Air pollution
- Alpha-1-antitrypsin deficiency (also causes cirrhosis and liver failure in a minority)
What is the management of COPD?
1.SABA (salbutamol) or SAMA (ipratropium)
2. LABA (salmeterol) or LAMA (tiotropium)
3. If on LABA, add on ICS. If declined/not tolerated/still symptomatic, add LAMA
4. If on LAMA, add LABA plus ICS
Maximum therapy is LAMA+LABA+ICS+SABA
Two other rules - 1) Stop SAMA if prescribing LAMA
- 2) Don’t use ICS monotherapy
When would you consider oxygen in COPD?
Consider in:
<30% FEV1
Cyanosis
Polycythaemia
Peripheral oedema
Raised JVP
O2 sats <92%
What is the prognosis of Heart failure?
50% die within 5 years of diagnosis
40% die or are re-admitted in 1 year
What are some poor prognostic indicators for HF?
-Reduced ejection fraction
-Comorbidities
-Worsening symptoms and signs
-Obesity/cachexia
-Smoking
-MI history
What are the signs and symptoms of HF?
Less specific - breathlessness, fluid retention, fatigue, syncope
More specific – orthopnoea, PND
Less specific – tachycardia, hypertension, tachypnoea, basal creps, oedema, obesity, heart murmurs
More specific – displaced apex, gallop rhythm, raised JVP, hepatomegaly, ascites
How do you diagnose HF?
ECG in everyone
Consider CXR, U+E, eGFR, FBC, TFTs, LFT, HbA1c, lipids, urinalysis
If history of MI, refer to cardio and organise echo within 2 weeks
If no history of MI, measure natriuretic peptide (BNP or NT-pro-BNP)
- If normal, heart failure unlikely
- If raised, refer to cardio and organise echo
How do you manage heart failure?
Review drugs to see if contributing to symptoms
Prescribe loop diuretic for symptomatic relief
Prescribe both an ACE-I and a B-blocker
Start one at a time, no recommended order
Refer if still symptomatic
Consider anti-platelet treatment
Consider statin therapy
Annual flu, and 1x pneumococcal, vaccines
Cardiac rehab
By which mechanism does ACEi cause a cough?
Bradykinin accumulation
How do you assess febrile child in primary care?
General appearance
- Temp
- Heart rate
- Resp rate
- CRT
- Fluid status
(Consider BP if HR or CRT abnormal)
Examine chest
Examine throat (NOT epiglottitis)
Red- high risk signs for paediatric illness in primary care
- Pale/mottled/ashen blue
- No response to vocal cues
- Appears sick to a healthcare professional
- Does not wake if roused
- Weak, high-pitched or continuous cry
- Resp signs –> Grunting, tachypnoea, RR>60breaths/minute, moderate or severe chest indrawing
- Reduced skin turgor
- Age <3months temperature >38C
- Non-blanching rash
- Bulging fontanelle
- Neck stiffness
- Status epilepticus / focal seizures
- Focal neurological signs
Overview of bronchiolitis in children?
-RSV, <1 year old, winter
-Coryza, fever, irritable cough, rapid breathing, difficulty feeding
-Tachypnoea, tachycardia, widespread crepitation -+/- high-pitched wheeze
-Management depends on severity of symptoms
-High risk – premature babies, babies < 6 weeks, underlying lung disease/congenital heart disease/immunosuppression.
Overview of croup?
Viral, autumn and spring
Mild fever and runny nose. Inspiratory stridor and barking cough – usually at night (<4 year).
Steam. Oral steroids – oral dex or pred
How will Kawasaki present in primary care?
Kawasaki – Vasculitis. >5 fever 5 days, bilateral conjunctivitis, polymorphous rash, strawberry tongue and lips, reddening or palms/soles, cervical lymphadenopathy singular large painful. Urgent referral. IV immunoglobulin and aspirin.
What is blindness?
inability to perform any work for which eyesight is essential. <3/60 vision.
(Partial sightedness – usually 3/60 – 6/60.)
What are some red flags for red eye?
Decreased visual acuity, pain deep in eye, absent/sluggish pupils, corneal damage, trauma
How does retinal vein occlusion present?
Sudden - typically on waking +/- afferent pupil defect
Retina – Pizza/storm sunset
Glaucoma, HTN, polycythaemia, cholesterol
Laser tx, intraocular steroids/growth factors
How does retinal artery occlusion present?
Sudden - afferent pupil defect
Retina – White +/- cherry red spot at macula
Thromboembolism
Treat risk factors. No reliable tx. Optic atrophy and blindness.
How does a vitreous haemorrhage present?
Sudden decreased vision, loss of red reflex, difficulty seeing retina
Diabetes, bleeding disorders, trauma, tumour, central retinal vein, retinal detachment
How does a retinal detachment present?
Painless – curtain
Symptoms pre-detachment – floaters/flash
Idiopathic, trauma, DM, myopia
Central vision depends on macula
Define the two types of age-related macular degeneration?
Most common cause of blindness in UK.
Dry – Atrophy of neuroretina. Macula cells break down and results in drusen formation.
Wet – Drusen lifts the retinal pigment epithelium from the bloods supply. New blood vessels grow from the choroid and can bleed forming scars.
What is the management of AMD?
Food supplements – can slow progression
Treat co-existing conditions
(Some biologics in secondary care)
Social support – IMPORTANT. Visual aids, register blindness, information, help groups/forums, blue badge parking scheme, disability living allowance.
What is Presbyacusis?
Common.
Bilateral sensorineural deafness in >50 years.
Gradual onset
High frequencies more severely affected
Examination normal
Audiology and hearing aids
What is noise-induced sensorineural deafness?
– Exposure >85 dB.
Bilateral
Occupational/non-occupational
Acute/gradual onset from repeated exposure
Immediate signs – ringing in ears/muffling
Audiology and hearing aids
Compensation/ear protection.
What is an acoustic neuroma?
Slow-growing – neurofibroma from acoustic nerve
Unilateral
Can get tinnitus and facial palsy
Refer to ENT
What is Meniere’s disease?
Idiopathic dilatation of endolymphatic spaces
Clustering of attacks of vertigo and nausea , tinnitus, sense of fullness, sensorineural deafness which can be progressive.
Minutes – hours
Refer to ENT
Acute attacks - Can give labrynthine sedatives, encourage to mobilise after, try and identify trigger
Long-term – meds, low-salt diet, vestibular rehab, hearing aids/tinnitus maskers
What is otosclerosis?
Adherence of stapes footplate to bone
Bilateral conductive hearing loss
FH
Refer to ENT – surgery
What is cholesteatoma?
Skin/stratified squamous epithelium in middle ear.
Retraction pocket in pars flaccida.
Local expansion can cause damage to local structures
Can get infected – offensive smell
Refer to ENT - surgery
Look out for red flags such as facial nerve palsy.
What is the incubation period of measles?
10-18 days. Infectious from 5 days before start of symptoms until rash appears
What are the Gillick competency and Fraser guidelines?
- Girl under 16 year will understand advice
- Cannot persuade to tell parents
- Likely to continue having sexual intercourse with/without tx
- Unless she receives contraceptive advice her physical +/ mental health will suffer
- Best interests require contraception without parental consent
What is the action of N-acetylcysteine?
Replenishes body stores of glutathione so that NAPQI can be converted to a less toxic product, preventing hepatocyte damage.
What can be used to reverse heparin?
Protamine
What is the management used post-MI?
ACEi + Beta Blocker + Statin + Aspirin + Clopidogrel
What is the most common nail sign of iron deficiency anaemia?
Koilonychia
What joints does osteoarthritis most commonly affect?
Large joints or joints of the hand
What crystals are seen in pseudogout?
Positively Birefringent crystals.
Calcium pyrophosphate
How do you calculate alcohol unit?
Units = Strength (ABV) x Volume (ml)
1000
What is the CENTOR Criteria?
Used to assess whether ABx are needed in acute tonsillitis
- History of fever
- Tonsillar exudates
- No cough
- Tender anterior cervical lymphadenopathy
What is the NICE criteria for diagnosing atopic dermatitis
itchy skin + 3/5 of:
Visible flexural eczema*
History of flexural eczema*
History of dry skin
History of asthma or allergic rhinitis (or history of atopy in 1st degree relative if <4 years)
Onset <2 years old (do not use if <4 years old)
or on the cheeks/extensors in children <18 months
What is the epidemiology of COPD?
An estimated 1.2 million people are living with diagnosed COPD in the UK, representing around 2% of the population. Around 30,000 people die from COPD each year, representing 26% of deaths from lung disease.
What are the spirometry stages of COPD?
Spirometry: FEV1 <80% of predicted; FEV1/FVC <0.7
Stage 1 Mild FEV1 ≥ 80% predicted
Stage 2 Moderate FEV1 50-79% of predicted
Stage 3 Severe FEV1 30-49% of predicted
Stage 4 Very Severe FEV1 <30% of predicted
What are UKMEC 4 criteria?
Absolute contraindications to contraception:
- Known or suspected pregnancy
- Smoker over the age of 35 who smokes >15 cigarettes
- Obesity
- Breast feeding <6 weeks post partum
- Fx of thrombosis before 45 years old
- Breast cancer or cancer within the last few years
- BRCA genes