Gout

Question 1

Hyperuricemia

Answer 1

Uric acid levels exceed soluble threshold- crystals begin to form
Causes- increased or decreased renal excretion of uric acid

Question 2

Crystal deposit

Answer 2

Crystals deposit in synovial fluid and other tissues
Immune system detects and start inflammation process releasing cytokines

Question 3

Acute gout

Answer 3

Neutrophils infiltrate the joint
Rapid onset of pain, redness, swelling

Question 4

Inter critical period

Answer 4

After acute attack - crystals remain, inflammation resolves
Periods between attacks vary, becoming short as disease progresses

Question 5

Chronic gout

Answer 5

Chronic hyperuricemia leads to large crystals in in joints, tendons and soft tissue
Chronic inflammation = joint destruction, deformities, functional impairment

Question 6

What is it?

Answer 6

Gout is a metabolic disorder characterized by the deposition of monosodium urate (MSU) crystals in joints and tissues, leading to acute and chronic inflammation. It results from hyperuricemia (elevated serum uric acid levels).