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Pathopharm Final > Gout > Flashcards

Gout Flashcards

1
Q

gout

A

uric acid metabolism

deposits of urate salts

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2
Q

gouty arthritis

A

urate crystals in synovial fluid

acute and painful inflammation

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3
Q

chronic tophaceous gout

A

advanced stage gout

tophi

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4
Q

uric acid

A

waste product of purine metabolism

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5
Q

what is purine

A

compound containing nitrogen

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6
Q

sources of purine

A 
alcohol
organ meat (liver)
red meat
seafood, shellfish
primarily excreted by kidneys
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7
Q

predisposing factors of gout

A 
male
genetics
diet
obesity
diuretic therapy + kidney insufficiency
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8
Q

pathogenesis of Gouty arthritis

A 
elevated uric acid levels
uric acid accumulates in body fluids
formation of urate crystals
deposition in or around joints
inflammation
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9
Q

gouty arthritis manifestations

A

pain (great LT toe, early morning)
edema, tenderness, redness
fever
malaise

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10
Q

complications of gout and gouty arthritis

A

uric kidney stones

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11
Q

Meds for acute gouty arthritis

A

NSAIDS
corticosteroids
colchicine

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12
Q

prophylactic meds for gouty arthritis

A

allopurinol
colchicine
probenecid

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13
Q

allopurinol

A

antigout
inhibits production of uric acid
given prophylaxis
se: rash

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14
Q

important drug interactions with allopurinol

A

hypoglycemic agents

warfarin

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15
Q

nursing implication for allopurinol

A

gastric irritation, take with milk or food
monitor serum/urine uric acid
monitor serum glucose (can cause hypoglycemia)
2-6 weeks before improvement

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16
Q

colchicine

A 
anti-inflammatory, anti-gout
inhibits leukocyte infiltration (disrupts cell division)
used for gout flares and prophylaxis
given orally
CONTRAINDICATED in renal disease
17
Q

side effects of colchicine

A

GI upset- stop colchicine

18
Q

nursing implications for colchicine

A

AVOID: alcohol, grapefruit, B12 vitamins

19
Q

types of drugs that have interactions with colchicine

A

CYP3A4 inhibitors: clarithromycin
digoxin (lanoxin)
statins

20
Q

probenecid

A

uricosuric agent
inhibits reabsorption of uric acid in kidney, promoting excretion
treats hyperuricemia with gout
can be used alone or in combo with allopurinol when not effective alone

21
Q

side effects of probenecid

A

GI upset
dizziness or headache
kidney/liver impairment
lots of drug interactions

Pathopharm Final (9 decks)

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