Gonads and reproductive disorder lab diagnostics

Question 1

1) The laboratory parameters of a 42-year-old man are: plasma prolactin and cortisol decreased, urinary 17-ketosteroid excretion is decreased, plasma prolactin level is not influenced by TRH. The administration of hCG increased the urinary excretion of 17-ketosteroids.
What is the possible diagnosis?

Answer 1

Panhypopituitarism

The hCG is a glycoprotein, with the same alpha chain, so it stimulated some androgen production, as LH and FSH would.

MRI, CT for possible tumors,

Question 2

2) The laboratory parameters of a 19-year-old man are: plasma testosterone decreased, FSH and LH are elevated, urinary 17-ketosteroid excretion is decreased. The administration of hCG did not increase plasma testosteron level or the urinary excretion of 17-ketosteroids.
What is the possible diagnosis?

Answer 2

Primary hypogonadism.

Check for:

cyrptorchidism

fever, high body temp

trauma

mumps

Question 3

3) The laboratory parameters of a 42-year-old man are: plasma testosterone increased significantly, FSH and LH are barely detectable, urinary excretion of androgens are increased. The right testis is enlarged.
What is the possible diagnosis?

Answer 3

Primary testosterone secreting testicular cancer.

or benign testosterone secreting testeroma.