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PHARM 3 > Gonadal hormones > Flashcards

Gonadal hormones Flashcards

1
Q

anastrozole

A

inhibits aromatase

- decrease effects of estrogen

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2
Q

ketoconazole

A

inhibits desmolase

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3
Q

letrozole

A

aromatase inhibitor

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4
Q

exemestane

A

aromatase inhibitor

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5
Q

fulvestrant

A

SERD

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6
Q

drospirennone

A

progestin

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7
Q

desogestrel

A

progestin

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8
Q

toremifene

A

SERM

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9
Q

clomiphene

A

SERM

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10
Q

norethindrone

A

progestin

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11
Q

norgestrel

A

progestin

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12
Q

mestranol

A

estrogen

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13
Q

nafarelin

A

GnRH analog

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14
Q

goserelin

A

GnRH analog

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15
Q

Ganirelix

A

GnRH anatagonist

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16
Q

mifepristone

A

antiprogestin

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17
Q

oxandrolone

A

androgen

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18
Q

stanozolol

A

androgen

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19
Q

fluoxymesterone

A

androgen

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20
Q

nandrolone

A

androgen

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21
Q

oxymetholone

A

androgen

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22
Q

danazol

A

androgen

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23
Q

finasteride

A

5-alpha reducatase inhibitor

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24
Q

flutamide

A

androgen receptor antagonist

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25
Q

bicalutamide

A

androgen receptor antagonist

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26
Q

nilutamide

A

androgen receptor antagonist

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27
Q

cyproterone

A

androgen receptor antagonist

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28
Q

spironolactone

A

androgen receptor antagonist

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29
Q

ketoconazole

A

steroid synthesis inhibitor

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30
Q

estradiol vs estrone vs estriol - which is most potent

A

estradiol

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31
Q

ethinyl estradiol MOA

A

stimulation of estrogen receptors = change rate of transcription

relies on P450

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32
Q

ethinyl estradiol use

A

prevent osteoporosis
HRT
OCP
hypogonadism

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33
Q

ethinyl estradiol AE

A 
breakthrough bleeding
thromboembolism
gallbladder diz
hyperTG
HTN
depression

post menopausal women: breast CA, endometrial hyperplasia

**pro-thrombotic drug - blocks AT3

taken with p450 inducer = breakthrough bleeding, dec contraceptive efficacy

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34
Q

mestranol

A

prodrug - converted to ethinyl estradiol

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35
Q

dietthlstilbestrol

A

nonsteroidal estrogen agonist used in pregnancy – can lead to infertility and vaginal cancer

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36
Q

estrogen esters

A

long acting estrogens - given IM and used for hypogonadism in young females

37
Q

weekly patch

A

ethinyl estradiol + norelgestromin

38
Q

monthly vaginal ring

A

ethinyl estradiol + etonogestrel

39
Q

IUD

A

L-norgestrel

40
Q

subcutaneous implant

A

etonogestrel

41
Q

depot IM

A

medroxyprogesterone

42
Q

postcoital contraceptive

A

L-norgestrel, combined oral contraceptive

43
Q

tx for intractable dysmenorrhea

A 
conjugated estrogens
ethinyl estradiol
OCP
depot inejction
GnRH agnoist
44
Q

infertility tx

A 
progesterone*
clomiphene
hMG and hCG
GnRH analogs
bromocriptine
45
Q

endometriosis tx

A

OCP
depot injection
GnRH agonist
danazol

46
Q

osteoporosis in postmenopausal women

A

conjugated estrogens
estradiol
raloxifene

47
Q

hirsutism

A

combined OCP
spirinolactone
flutamide
GnRH agonist

48
Q

progesterone functions

A

stimulate endometrial glandular secretion

pro-gestation
dec myometrial contraction

inc body temp

thick cervical mucus

prevent endometrial hyperplasia

49
Q

norgestrel AE

A

weight gain
dec in bone density

low HDL, inc LDL, HTN

50
Q

drospirenone

A

progestin of spironolactone derivative

51
Q

tamoxifen

A

SERM - estrogen antag at breast and CNS. agonist in endometrium, liver and bone

52
Q

tamoxifen AE

A

hot flush
thromboembolism
endometrial hyperplasia

53
Q

raloxifene vs tamoxifene

A

protect against osteoporosis
antagonist effects in breast and CNS and endomterium

**bone density increases with raloxifene

54
Q

clomiphene

A

induced ovulation

ER antagonist effect in pituitary = gonadotropin secretion increased

55
Q

clomiphene AE

A

hyperstimulation of ovary = hypertrophy

multiple pregnancy

hot flush, n/v, weight gain

56
Q

fulvestrant MOA

A

estrogen antagonist in all tissues = SERD

57
Q

fulvestrant use

A

tx for hormone responsive breast CA that is resistant to first lines

IM admin

58
Q

fulvestrant AE

A

hot flush, HA, injection site reactions

59
Q

anastrozole MOA

A

inhibits aromatase = dec estrogen synthesis

60
Q

anastrozole use

A

tx for hormone responsive breast CA

oral admin

61
Q

anastrozole AE

A

musculoskeletal disorder, dec bone density, hot flushes

joint sxs: spondylosis, osteoarhtritis, disk herniation

62
Q

letrozole

A

similar to anastrozole

63
Q

exemestane

A

irreversible aromatase inhibitor

64
Q

leuprolide use

A 
ovarian suppresion
control ovarian hyperstimulation
central precocious puberty
block endogenous puberty in transgender
adv prostate cancer
65
Q

Leuprolide AE

A

continued use - may show signs of hypogonadism

light headed, HA, nausea

66
Q

GnRH analogs

A 
goserelin
histrelin
nafarelin
triptorelin
gonadorelin
67
Q

ganirelix MOA

A

GnRH antagonist

68
Q

ganirelix use

A

prevention of premature LH surges during controlled ovulation hyperstimulation

69
Q

cetrorelix

A

similar to ganirelix

70
Q

degarelix

A

used for adv prostate CA

71
Q

Danazol

A

partial agonist of progestin and androgen receptors

*p450 inhibtior

72
Q

danazol use

A

endometriosis

fibrocystic breast

73
Q

danazol AE

A

acne
hirsutism
weight gain
menstrual disturbance

74
Q

mifepristone

A

antiprogestin

progestin and glucocorticoid blocker

75
Q

mifepristone use

76
Q

dihydrotestosterone vs testosterone vs androstenedione - potency?

A

DHT most potent

77
Q

what drug is used for wasting syndromes?

A

testosterone - helps with weight gaining

78
Q

oral testosterone

A

fluoxymesterone

methyltestosterone

79
Q

long acting androgens for parenteral admins

A

testosterone esthers

80
Q

finasteride use

A

BPH
male patterned hair loss

oral admin

81
Q

finasteride AE

A

impotence

gynecomastia

82
Q

dutasteride

A

similar to finasteride

83
Q

flutamide MOA

A

competitive inhibition of androgen receptor

84
Q

flutamide use

A

adv prostate cancer

85
Q

flutamide AE

A

gynecomastia
hot flush
impotence
hepatotoxicity

86
Q

bicalutamide

A

flutamide like - lower liver toxicity risk

87
Q

nilutamide

A

flutamide like - lower liver toxicity risk

88
Q

cyproterone

A

used in hirsutism and to decrease excessive sexual drive in men

PHARM 3 (21 decks)

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