Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

PHARM 3 > adrenocorticosteroids > Flashcards

adrenocorticosteroids Flashcards

1
Q

mifepristone

A

gluocorticoid antagonist

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

spirnolactone

A

mineralcorticoid antagonist

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

ketoconazole

A

corticosteroid synthesis inhibitor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

aminoglutehimide

A

corticosteroid synthesis inhibitor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

metyrapone

A

corticosteroid synthesis inhibitor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

fludrocortisone

A

mineralcorticoid agonist

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

major effects of cortisol

A

1) gluconeogenesis and 2) glycogen synthesis = maintains hepatic glycogen in fasting state
- - inc glucose levels

stimulate lipolysis

stimulate protein catabolism

net = maintain adequate glucose to brain

catabolic effects = wasting to lymphoid, CT, muscle, fat, skin, osteoporosis, growth retardation

immunosuppressive =

  • inc neutrophils (inc influx and dec migration form BV)
  • dec lymphocytes, monocytes, eosinophils, basophils
  • vasoconstriction - d/t mast cell degranulation

anti-inflamm

  • inhibit PLA2 - blocking arachidonic acid, COX2
  • induction of MAPK-phosphatase 1

CNS: behavioral changes - insomnia/euphoria
Inc ICP
Suppress ACTH, growth hormone, TSH, LH
Peptic ulcers (stimulate gastric acid and suppress immune response to h. pylori)

  • Inc platelets, RBC
  • renal function is impaired with cortisol deficiency
  • develop fetal lungs
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

which glucocorticoid has a short t 1/2

A

beclomethasone

- penetrates airway mucosa

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

which glucocorticoid can be given IM

A

triamcinolone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

which 2 glucocorticoids can be given with aerosol

A

beclomethasone
triamcinolone

good for asthma, or pt that you don’t want to systemic effects

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

which glucocorticoids can be given systemic

A

beclomethasone
dexamethasone
hydrocortisone
triamcinolone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

mineralocorticoids MOA

A

inc expression of Na/K ATPase and ENaC

  • promote Na reabsorption from renal tubule
  • promote K and H excretion
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

short to medium acting glucocorticoids

A

hydrocortisone
prednisone
methylprednisolone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

intermediate acting glucocorticoid

A

traimcinolone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

long acting glucocorticoid

A

dexamethasone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

which glucocorticoid has 1:1 anti inflamm to salt retaining

A

hyrocortisone

17
Q

which glucocorticoids has 0 salt retaining effects

A

triamcinolone
dexamethasone

these wouldn’t be good for addison’s (loss of both gluoccorticoid and mineracorticoid)

18
Q

treat addison’s

A

daily hydrocortisone (increase before stress) + mineralocorticoid (fludrocortisone)

don’t give glucocorticoids lacking salt retaining effects**

19
Q

tx ACUTE adrenocortical insufficiency

A

large amoutns of parenteral hydrocortisone + correction of fluid, electroyltes

can give fludrocortisone once hydrocortisone levels are reduced

20
Q

tx congenital adrenal hyperplasia

A

intially: treat like acute adnreal crisis

once stabilized = oral hydrocortisone/prednisone + fludrocortisone

21
Q

tx cushings syndrome

A

remove tumor
radiation
resection of both adrenals

tx with high doses of cortisol before and after surgery - slowly decrease to prevent withdrawal

22
Q

tx alodsteronism

A

spirnolactone

23
Q

lung maturation in fetus

A

IM dexamethasone

24
Q

hodgkins lymphoma tx

A

prednisone

25
Q

cerebral edema tx

A

dexamethasone

26
Q

idiopathic orthostatic hypotension tx

A

fludrocortisone

27
Q

corticosteroid AE

A 
metabolic - cushingoid, DM, osteoporosis
peptic ulcers
infections
myopathy (long term)
CNS - euphoria
increased IOP
subcapsular cataracts
growth retardation
adrenal suppresion

**abrupt withdrawal can cause adrenal insufficiency

28
Q

corticosteroid contraindication

A 
peptic ulcers
HTN, HF
TB, zoster infection
psychoses
DM
osteoporosis
glaucoma
29
Q

spirnolactone

A

competitive antagonist = decreases effect peripherally

use = aldosteronism, hirsutism, diuretic

30
Q

spirnolactone AE

A

hyperkalemia
cardiac arrythmias
gynecomastia
rash

31
Q

mifepristone use

A

inoperable pt with ectopic ACTH syndrome or adrenal carcinoma

32
Q

aminogluthethimide

A

corticosteroid synthesis inhibitor

block conversion of cholesterol to preneolone = reduce synthesis of all hormonally active steroids

33
Q

aminoglutethimide use

A

adrenal cancer (+ hydrocortisone/dexamethasone)

34
Q

ketoconazole use

A

cushing’s syndrome

prostate cancer

35
Q

metyrapone

A

selective inhibitor of steroid 11 hydroxylation = interferes with cortisol and corticosterone synthesis

36
Q

metryapone use

A

tests adrenal function

tx pregnant women with cushing’s

37
Q

tx pregnant female with cushing

A

metyrapone

38
Q

metyrapone AE

A

salt and water retention
hirsutism
transient dizziness
GI disturbances

PHARM 3 (21 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions