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PHARM 3 > antipsychotics > Flashcards

antipsychotics Flashcards

1
Q

classical vs atypical antipsychotic: chlorpromazine

A

classical

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2
Q

classical vs atypical antipsychotic: fluphenazine

A

classical

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3
Q

classical vs atypical antipsychotic: haloperidol

A

classical

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4
Q

classical vs atypical antipsychotic: thioridazine

A

classical

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5
Q

classical vs atypical antipsychotic: clozapine

A

atypical

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6
Q

classical vs atypical antipsychotic: risperidone

A

atypical

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7
Q

classical vs atypical antipsychotic: olanzapine

A

atypical

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8
Q

classical vs atypical antipsychotic: quetiapine

A

atypical

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9
Q

classical vs atypical antipsychotic: ziprasidone

A

atypical

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10
Q

classical vs atypical antipsychotic: aripiprazole

A

atypical

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11
Q

classical vs atypical antipsychotic: paliperidone

A

atypical

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12
Q

classical antipsychotics

A

high potency - higher chance for EPRs

  • fluphenazine
  • haloperidol

low potency - more likely to cause sedation, postural hypotension

  • chlorpromazine
  • thioridazine
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13
Q

atypical antipsychotics

A

higher affinities for receptors other than D2

commonly:

  • antagnoize 5HT2a and D2
  • less likely to cause tardive dyskinesia, inc prolactin
  • effective in treating negative sxs
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14
Q

clozapine

A

prototype for atypicals

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15
Q

risperidone

A

causes EPR - rare at normal dose

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16
Q

paliperidone

A

9-hydroxyrisperidone (active metabolite of risperidone)

17
Q

which antipsychotics are least likely to induce EPR

A

clozapine

quetiapine

18
Q

aripiprazole

A

patial agonist at D2 and 5HT1a

antag at 5HT2a

19
Q

all antipscyhotics except which 2 don’t have anti-emetic effects

A

aripiprazole
thioridazine

mediated via D2 blocking

20
Q

neurological AE of anti-psychotics

A

EPS = with high D2 potency
(haloperidol, fluphenazine - high D2 affinities)

also less likely with strong anticholinergics (thioridazine/chlorpromazine) and atypicals

21
Q

tx for parkinsonism AE of antipsychotics

A

benztropine
trihexyphenidyl
diphenhydramine/amantadine

never give levodopa = will aggravate psychosis

22
Q

tx for dystonia AE of antipsychotics

A

benztropine
trihexyphenidyl
diphenhydramine

23
Q

tx for akathisia AE of antipscyhotics

A

clonazepam

propranolol

24
Q

tx for tardive dyskinesia AE of antipsychotics

A

(may be due to dopamine receptor up regulation)

may be irreversible

eliminate drugs with central anticholinergic actions (anti-parkinsonian drugs and TCAs)

diazepam may help

25
Q

pt with tardive dyskinesia who require antipsychotics - what drug to use

A

clozapine

26
Q

neuroleptic malignant syndrome

A

rigidity, tremor, hyperthermia
inc WBC, inc CK
myoglobinemia

tx: dantrolene, bromocriptine

27
Q

what causes sedation as an AE of antipsychotics

A

blockade of central H1

28
Q

autonomic AE of antipsychotics

A

orthostatic hypotension

impaired ejaculation

29
Q

which antipsychotic causes agranulocytosis

A

clozapine

regular blood counts are mandatory

NOT first line

30
Q

AE prolactin elevation with antipsychotics

A

blockade of D2

amenorrhea, galactorrhea
loss of libido, infertility in men

31
Q

which antipsychotics can cause cardiac toxicity

A

thioridazine = QT elongation, T wave changes

ziprasidone = can elongate QT

32
Q

which antipsychotics cause ocular AE

A

chlorpromazine = cornea, lens deposits

thioridazine = retinal spots

33
Q

non pysch use for antipsych meds

A

nausea and vomiting

droperidol used in neurolept-anesthesia

34
Q

DOC antipsychotics

A

atypical

risperidone is most prescribed

35
Q

antipsych in pregnancy

A

category C

only clozapine is category B

risk of hyperglycemia and weight gain are greater with use atypicals

PHARM 3 (21 decks)

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