Glycopeptides

Question 1

MOA

Answer 1

• Only active against gram +ve bacteria, including MRSA
• Blocks cell wall synthesis by preventing cross linking of peptidoglycan chain (bactericidal)
• Narrow spec

Question 2

Examples of glycopeptides

Answer 2

• Vancomycin
• Tecioplanin (similar to vancomycin, long half life: OD)

Question 3

What are the indications of glycopeptides?

Answer 3

• C diff
• MRSA
• Complicated skin + soft tissue
• Endocarditis

Question 4

What is the route of glycopeptides?

Answer 4

Parenteral

Question 5

What is the therapeutic index of glycopeptides?

Answer 5

10-20MG/L PRE DOSE
Regular monitoring:
- Renal impairment
- High dose + long term
- Impaired hearing
- Ototoxic/nephrotoxic drugs

Question 6

Pregnancy + glycopeptides?

Answer 6

Avoid

Question 7

What are the side effects of glycopeptides?

Answer 7

Ototoxicity
- Monitor: auditory + vestibular function

Nephrotoxicity
- Monitor: renal function

Blood dyscrasias
- Monitor: blood count

Red man syndrome