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High - Infections > Glycopeptides > Flashcards

Glycopeptides Flashcards

1
Q

MOA

A
  • Only active against gram +ve bacteria, including MRSA
  • Blocks cell wall synthesis by preventing cross linking of peptidoglycan chain (bactericidal)
  • Narrow spec
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2
Q

Examples of glycopeptides

A
  • Vancomycin
  • Tecioplanin (similar to vancomycin, long half life: OD)
  • Oritavancin (skin infections)
  • Dalbavancin (skin infections)
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3
Q

What are the indications of glycopeptides?

A
  • C diff
  • MRSA
  • Complicated skin + soft tissue
  • Endocarditis
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4
Q

What is the route of glycopeptides?

A

Parenteral

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5
Q

What is the therapeutic index of glycopeptides?

A

10-20MG/L PRE DOSE
Regular monitoring:
- Renal impairment
- High dose + long term
- Impaired hearing
- Ototoxic/nephrotoxic drugs

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6
Q

Pregnancy + glycopeptides?

A

Avoid

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7
Q

What are the side effects of glycopeptides?

A

Ototoxicity
- Monitor: auditory + vestibular function
Nephrotoxicity
- Monitor: renal function
Blood dyscrasias
- Monitor: blood count
Red man syndrome

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High - Infections (27 decks)

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