Cephalosporin Flashcards
1
Q
What is the mechanism of action of cephalosporins?
A
- Prevents peptidoglycan cross lining in bacterial cell walls (bactericidal)
- Broad spec
2
Q
What are the indications of cephalosporins?
A
Don’t treat CNS infections except meningitis
- UTI
- RTI
- Serious infections
3
Q
Give examples of cephalosporins
A
1st gen:
- Cefalexin
- Cefadroxil (BD)
2nd gen:
- Cefaclor (protracted skin reactions)
- Cefuroxime (take after food)
3rd gen:
- Cefixime (orally active)
- Ceftriaxone
4
Q
What are the side effects of cephalosporins?
A
Abx associated colitis (3rd + 4th gen)
Cross sensitivity in penicillin allergy
- Immediate hypersensitivity → if essential: 3rd gen OR cefuroxime
5
Q
What are the interactions of cephalosporins?
A
INC nephrotoxicity
- Aminoglycosides, ciclosporins, methotrexate, NSAIDs
Warfarin → bleed
