Glycopeptide antibiotics Flashcards
What is it indicated for?
Treatment of complicated skin and soft tissue, bone and joint infections and infective endocarditis
Vancomycin- first-line treatment of C.difficile
What is the spectrum of activity?
Relatively narrow spectrum of activity against gram-positive bacteria
How do they work?
They inhibit growth and cross-linking of peptidoglycan chains. Inhibiting cell wall synthesis
What side effects occur with these drugs?
Pain and thrombophlebitis from vancomycin IV
Rapid-infusion of vancomycin can cause red man syndrome due to release of non-immune histamine. Causing a rash over the upper-body and hypotension
Immune-mediated allergy to glycopeptide antibiotics including delayed hypersensitivity
Can cause nephrotoxicity and ototoxicity
Rarely it neutropenia, thrombocytopenia and severe cutaneous adverse reactions
What are the warnings of drugs in this class?
Use in caution with people with immune-mediated hypersensitivity, hearing impairment, reduced renal function
What are the drug interactions that can occur with this drug class?
Increased risk of ototoxicity or nephrotoxicity when prescribed with drugs that cause these effect like loop diuretics, aminoglycosides, NSAIDs and ciclopsorin
What are the names of drugs in this class?
vancomycin, teicoplanin
