Glycolysis/Gluconeogenesis Flashcards

1
Q

What are the irreversible enzyme reactions in Glycolysis?

A
  1. Glucose to Glucose 6-P by Hexokinase
  2. PFK-1 to convert F6-P to F1,6 BisP
  3. Pyruvate Kinase to convert PEP into Pyruvate
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2
Q

Pyruvate is turned into acetyl co-A where? By what? How did it get there

A

In the mitrochondria by a pyruvate transporter. Converted by Pyruvate dehydrogenase Complex (PDC)

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3
Q

What products will inhibit the PDC in acetyl-CoA production? What phosphorylation state inhibits it?

A

ATP, NADH, and Acetyl-CoA. Phosphorylation of complex will inhibit it.

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4
Q

What cofactors are required for the conversion of Pyruvate into Acetyl-CoA?

A
  1. Coenzyme A,
  2. NAD+,
  3. TPP,
  4. Lipoic acid,LipoateLipoamide
  5. FAD
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5
Q

Insulin regulates glycolysis by doing what two things? glycolysis activated or inhibited?

A
  1. Inhibits Fructose 2,6-BisPase, Increasing F 2,6 BisP
  2. Dephosphorylates PK, Activating it
    - Overall it activates glycolysis
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6
Q

Glucagon regulates glycolysis by doing what? Glycolysis activated or inhibited?

A

Glucagon activates cAMP signaling, which increases PKA, which activates Fructose 2,6-bisPase, reducing Fructose 2,6-BisP. It also Phosphorylates PK, inactivating it. This inhibits glycolysis.

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7
Q

Where does anaerobic glycolysis occur?

A
  1. Red blood cells
  2. Vigorously working muscles
  3. Ischemia
  4. Tumors
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8
Q

What is the cori cycle? What products from where?

A

Catablolism of glucose in skeletal/red blood cells into lactate, then anabolism of lactate to glucose in the liver.

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9
Q

In beta-Oxidation, what are the resulting molecules?

A

2 molecules cleaved off for an 1 Acetyl-CoA, an NADH and FADH.

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