Glycolysis/Gluconeogenesis Flashcards
What are the irreversible enzyme reactions in Glycolysis?
- Glucose to Glucose 6-P by Hexokinase
- PFK-1 to convert F6-P to F1,6 BisP
- Pyruvate Kinase to convert PEP into Pyruvate
Pyruvate is turned into acetyl co-A where? By what? How did it get there
In the mitrochondria by a pyruvate transporter. Converted by Pyruvate dehydrogenase Complex (PDC)
What products will inhibit the PDC in acetyl-CoA production? What phosphorylation state inhibits it?
ATP, NADH, and Acetyl-CoA. Phosphorylation of complex will inhibit it.
What cofactors are required for the conversion of Pyruvate into Acetyl-CoA?
- Coenzyme A,
- NAD+,
- TPP,
- Lipoic acid,LipoateLipoamide
- FAD
Insulin regulates glycolysis by doing what two things? glycolysis activated or inhibited?
- Inhibits Fructose 2,6-BisPase, Increasing F 2,6 BisP
- Dephosphorylates PK, Activating it
- Overall it activates glycolysis
Glucagon regulates glycolysis by doing what? Glycolysis activated or inhibited?
Glucagon activates cAMP signaling, which increases PKA, which activates Fructose 2,6-bisPase, reducing Fructose 2,6-BisP. It also Phosphorylates PK, inactivating it. This inhibits glycolysis.
Where does anaerobic glycolysis occur?
- Red blood cells
- Vigorously working muscles
- Ischemia
- Tumors
What is the cori cycle? What products from where?
Catablolism of glucose in skeletal/red blood cells into lactate, then anabolism of lactate to glucose in the liver.
In beta-Oxidation, what are the resulting molecules?
2 molecules cleaved off for an 1 Acetyl-CoA, an NADH and FADH.