Glycolysis

Question 1

What is the committing step in glycolysis?

Answer 1

Step 3 - the conversion of fructose-6-P to fructose-1,6-bis P by PFK

Question 2

What inhibits hexokinase?

Answer 2

High glucose 6-P

Question 3

What are the key enzymes involved in glycolysis?

Answer 3

Hexokinase, PFK and pyruvate kinase

Question 4

Why are there so many steps in glycolysis?

Answer 4

Chemistry easer, gives versatility and allows for fine control

Question 5

Why do you phosphorylates glucose?

Answer 5

Makes glucose negatively charged therefore prevents passage back across plasma membrane. Also makes the glucose more reactive

Question 6

What are the two phases of glycolysis?

Answer 6

Investment phase and payback phase

Question 7

What does PFK stand for?

Answer 7

Phosphofructoskinase

Question 8

What is the hormonal regulation of PFK?

Answer 8

Stimulated by insulin

Inhibited by glucagon

Question 9

What is the allsoteric regulation of PFK?

Answer 9

Inhibited by high ATP

Stimulated by high AMP

Question 10

What stimulates pyruvate kinase?

Answer 10

Stimulated by high insulin:glucagon ratio ie high insulin and low glucoagon