glycolysis Flashcards
hexokinase
Glucose —-> Glucose 6 Phosphate
ATP —> ADP
delta G = negative
phosphohexose isomerase
Glucose 6 Phosphate —> Fructose 6 Phosphate
delta G = +
requires Mg2+
reversible
phosphofructo kinase
Fructose 6 Phosphate ---> Fructose 1,6 bisPhosphate ATP ---> ADP requires Mg2+ - inhibited by ATP and Citrate - activated by ADP and AMP
aldolase
Fructose 1,6 bisPhosphate —> Dihydroxy acetone + Glyceraldehyde 3 Phosphate
delta G = +
reaction pulled forward by next reaction
reversible
triose phosphate isomerase
Dihydroxy Acetone —> Glyceraldehyde 3 Phosphate
reversible
glyceraldehyde 3 phosphate dehydrogenase
Glyceraldehyde 3 phosphate —> 1,3 bisphosphogylcerate
NAD+ —> NADH + H+
requires Pi
reversible
phosphoglycerate kinase
1,3 bisphospho glycerate ---> 3 phosphoglycerate ADP ---> ATP requires Mg2+ substrate level phosphorolation reversible
phosphoglycerate mutase
3 phosphoglycerate —> 2 phosphoglycerate
requires Mg2+
reversible
enolase
2 phosphoglycerate —> phosphoenol pyruvate
reversible
removes a water
pyruvate kinase
phosphoenol pyruvate —> pyruvate
ADP —> ATP
delta G = -
requires Mg2+ and K+