Glycogen Metabolism and Regulation Flashcards
What kind of bonds and branches does glycogen have?
α-1,4-glycosidic bonds with α-1,6-branches, every 8 to 10 residues.
What is the regulated enzyme in the glycogen synthesis pathway?
glycogen synthase
what serves principally for maintaining the blood glucose during fasting conditions?
liver glycogen
In the liver, under fasting conditions, what are the blood glucagon, insulin, and cAMP tissue levels? What are the response of the tissue?
blood glucagon: ↑ insulin: ↓ cAMP tissue: ↑ glycogen degradation: ↑ glycogen synthesis: ↓
In the liver, under carbohydrate meal conditions, what are the blood glucagon, insulin, glucose, and cAMP tissue levels? What are the response of the tissue?
blood glucagon: ↓ insulin: ↑ Glucose: ↑ cAMP tissue: ↓ glycogen degradation: ↓ glycogen synthesis: ↑
In the liver, under exercise conditions, what are the blood, glucose, ca2+ calmodulin, and cAMP tissue levels? What are the response of the tissue?
blood epinephrine: ↑ Glucose: ↑ cAMP tissue: ↑ ca2+ calmoduin: ↑ glycogen degradation: ↑ glycogen synthesis: ↓
In the muscle, under fasting conditions, what are the blood insulin levels? What are the response of the tissue?
insulin: ↓
glycogen transport: ↓
glycogen synthesis: ↓
In the muscle, under carbohydrate meal rest conditions, what are the blood insulin levels? What are the response of the tissue?
insulin: ↑
glycogen synthesis: ↑
glycogen transport: ↑
In the muscle, under exercise conditions, what are the blood, ca2+ calmodulin, tissue and cAMP tissue levels? What are the response of the tissue?
blood epinephrine: ↑ cAMP tissue: ↑ ca2+ calmoduin: ↑ cAMP: ↑ glycogen degradation: ↑ glycogen synthesis: ↓ glycolysis: ↑
