Glycogen Metabolism

Question 1

What is Glycogen?

Answer 1

Storage of carbohydrates

- Upon hydrolysis, Glucose formed.

Question 2

List TWO sites where glycogen is stored

Answer 2

• Liver

- Muscle cells

Question 3

How is Glucose linked in Glycogen production?

Answer 3

• Linear = a(1-4) link

- Branched = a(1-6) link

Question 4

In glycogen, how frequently do glucose branches occur?

Answer 4

every tenth residues (units)

Question 5

How many residues (units) form a single glycogen chain?

Answer 5

12-14 glucose residues

Question 6

List the 3 steps of Glycogenolysis.

Answer 6

• Addition of a phosphate causes glucose to dissociate from chain (Glucose binds to Pi upon release, forming G1P)
• G1P to G6P
• G6P to Glucose

Question 7

List 3 molecules required for the synthesis of glycogen

Answer 7

• high [glucose] present
• UTP (energy source, turning into UDP)
• Glycogenin (incorperated with glucose to produce glycogen)

Question 8

List the 2 steps involved in UDP-glucose to glycogen

Answer 8

• Incorporation of Glycogenin with the removal of UDP (glucose-UDP to glucose subunits)
• Incorporation of glucose into the glycogen chain (non-reducing end)

Question 9

List the 4 steps of glycogenesis

Answer 9

• Glucose to G6P
• G6P to G1P
• G1P to UDP-glucose (Use of UTP)
• UDP-glucose to glycogen

[glycogen = a(1-4) & a(1-6) glucose]

Question 10

State the 2 glucose linkage sequences in a glycogen chain.

- e.g. alpha(?->?)

Answer 10

Linear, a(1->4)

Branched, a(1->6)

Question 11

State the 3 UDP-glucose constituents

Answer 11

• Uridine (uracil)
• Di-phosphate
• Glucose

Question 12

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Answer 12

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