Glycogen and pentose phospahte shunt Flashcards
1
Q
- Describe the structure of glycogen and why this is important.
A
glycogen is branched, rapid strorage and mobilization, 1-4 is linear bond, 1-6 is kinked bond
2
Q
first thing we do to glucose to shunt it toward glycogen
A
UDP-glucose
3
Q
what takes UDP glucose to GLycogen?
A
Glycogen synthase and brnaching enzyme
4
Q
What regulates glycogen synthase?
A
+ glucose 6-P
-glucagon–> Phosphorylates it
5
Q
what breaks glycogen down?
A
debranching enzyme and glycogen phosphorylase
6
Q
How is glycogen phosphorylase regulated?
in liver?
in muscle?
A
\+glucagon \+CA2+ muscle only, +AMP muscle only -glucose liver only - ATP, glucose 6-P -Insulin
7
Q
- Describe the clinical presentation of G6PD deficiency.
A
hemolytic anemia after taking fava beans or some drug
8
Q
what is purpose of pentose phosphate shunt
A
create NADPH, Reduce glutithione, make ribose sugars
9
Q
what are the important enzymes in the pentose phosphate pathway?
A
G6PD, glutathione reductase
