Glyburide

Question 1

What are Glyburide’s brand names?

Answer 1

DiaBeta, Glynase

Question 2

What is Glyburide’s therapeutic category?

Answer 2

Antidiabetic agent

Question 3

What are Glyburide’s indications?

Answer 3

Type 2 diabetes mellitus, adjunct to diet and exercise, noninsuling dependent (NIDDM)

Question 4

What is Glyburide’s usual adult dose?

Answer 4

Initial dose: 1.25-5mg once daily
Maintenance: 1.25-20mg/day given as single or divided doses
MAX: 20mg/day
Micronized initial: 1.5-3mg daily, maintenance .75-12mg/day
MAX: 12 mg/day

Question 5

What are Glyburide’s common side effects?

Answer 5

hypoglycemia, GI (heartburn, nausea), photosensitivity

Question 6

What are Glyburide’s monitoring parameters?

Answer 6

Fasting blood glucose, urine glucose
HbA1c
Signs/symptoms of hypoglycemia

Question 7

What are Glyburide’s available dosage forms?

Answer 7

Oral tablet: 1.25mg, 2.5mg, 5mg

Oral micronized tablet: 1.5mg, 3mg, 6mg

Question 8

What are Glyburide’s counseling points?

Answer 8

Monitor for signs of hyper or hypoglycemia
Take at the same time each day (usually with breakfast)
Caution of alc consumption
Caution in patients with severe sulfonamide allergy