Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pharmacology of CNS > Glutamate > Flashcards

Glutamate Flashcards

1
Q

Excitatory or Inhibitory?

A

Excitatory

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Reuptake by….

A

Excitatory Amino Acid Transporters (EAAT)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

How does glutamate bind so many receptors?

A

Not a rigid molecule
Can rotate along 2 different axis (AB and BY)
Can adopt different conformations (9 Rotamers possible)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

How many rotamers of glutamate are possible?

A

9

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

How many subunits do glutamate receptors have?

A

4

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Which subunits of glutamate receptors are transmembrane?

A

1,3 and 4

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Which subunit of glutamate does NOT span the membrane?

A

2 (p-element)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

How many classes of glutamate receptor are there?

A
  1. (NMDA, AMPA and KA)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

How does the AMPA receptor work?

A
  • Permeable to NA in and K out (Ca if no GluR2 subunit)

- FAST excitatory transmission

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What are the agonists of AMPA receptors?

A

Glutamate, AMPA, KA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What are the antagonists of AMPA receptors?

A

CNQX, NBQX

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

How does the NMDA receptor work?

A
  • Passes Na, K and Ca ions
  • Voltage AND Ligand gated
  • Large, SLOW depolarization
  • Dual gating
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

How many subunits does NMDA receptors have?

A
  • 4.

- 1 NR1 subunit and 3 NR2A-D subunits

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What are the agonists of NMDA receptors?

A

Glutamate, NMDA, Aspartate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What are the antagonists of NMDA receptors?

A

2-AP5, CPP, PCP, Ketamine, MK801

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Describe NMDA receptor dual gating

A
  • Glutamate alone = No current flows
  • Depolarisation removes the Mg block which allows the current to now flow
  • Means NMDA receptors need ligand and depolarisation to work
17
Q

What type of receptor are MGluRs?

A

GPCR

18
Q

How many TM-Regions do MGluRs have?

A

7

19
Q

Which mGluRs are postsynaptic?

A

1 and 5

20
Q

Which mGluRs are presynaptic?

A

2 ,3, 4, 7 and 8

21
Q

What is the role of postsynaptic mGluRs?

A

Slow depolarisation, release Ca

22
Q

What is the role of presynaptic mGluRs?

A

Inhibit glutamate release

23
Q

What glutamate receptors are presynaptic?

A

KAR, NMDA, mGluR

24
Q

What glutamate receptors are postsynaptic?

A

KAR, NMDA, mGluR, AMPA

Pharmacology of CNS (15 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions