GABA Flashcards
1
Q
Where is GABA found?
A
Everywhere
2
Q
Inhibitory or Excitatory?
A
Inhibitory
3
Q
Deficits in GABAergic neurotransmission are implicated in:
A
Epilepsy and Anxiety
4
Q
GABA is synthesized from?
A
Glutamate
5
Q
GABA is metabolised to?
A
Succinate
6
Q
What type of receptor are GABA(A)?
A
Ligand gated ion channels (Cl-)
7
Q
What type of receptor are GABA(B)
A
GPCR (K/Ca)
8
Q
GABA(A) are what type of ion channel?
A
Cl-
9
Q
What are the agonists of GABA(A) receptors?
A
GABA and Muscimol
10
Q
What are the antagonists of GABA(A) receptors?
A
Bicuculline
11
Q
What are the agonists of GABA(B) receptors?
A
GABA and Baclofen
12
Q
What are the antagonists of GABA(B) receptors?
A
Saclofen and CGPs
13
Q
What is the time course of GABA(A) receptors?
A
ms
14
Q
What is the time course of GABA(B) receptors?
A
ms-mins
15
Q
How do GABA(A) receptors work?
A
- They mediate fast HYPERpolarisation and there inhibition.
- GABA binds between A/B
- Benzodiazepines bind between A/Y
