Glucuronidation

Question 1

What are the possible conjugated groups involoved, including 2 that are vey rare?

Answer 1

OH, COOH,NH2,NR2,

Very rare: CH and SH

Question 2

What does the reaction do?

Answer 2

A glucuronic acid group: C6H9O6 will attach to one of the groups listed in the last question to form a more polar drug for rapid elimination.

Question 3

Give an example drug that would initially undergo Phase 1 ester hydrolysis, and then Phase 2 glucuronidation, and what functional groups would the final products be, and which one would be formed in a greater quantity than the other?

Answer 3

Aspirin. Either an ester or an ether group with a glucuronic acid is formed. However, there is twice as much ether glucuronide than ester glucuronide.

Question 4

Give an example of a common Glucuronidation

Answer 4

N-Glucuronidation where a Tertiary amine undergoes Glucuronidation to form a New compound with a Positive N (N+) because nothing is lost from the N, it only gains a bond (so the N loses a lone pair so becomes +ive)

Question 5

Give an example of a very rare Glucuronidation reaction:

Answer 5

C-glucuronidation where a Hydrogen is substituted with a glucuronic acid group. These are not used in humand (only as drugs used in horses)