Background Flashcards
1
Q
What is the general rule of drug metabolism?
A
Generally, drugs undergo Phase 1 metabolism, followeed by Phase 2 metabolism to make the drug even more polar for elimination.
2
Q
What is the exeptions to the rule?
A
Some drugs may go straight to Phase 2 metabolism
Some drugs are metabolised to form more LIPOPHILIC compounds, and these undergo more biotransformation before elimination
3
Q
What is Conjugation, and what enzymes are involved?
A
The covalent attachment of small hydrophilic molecules to form water soluble compounds that are more hydrophilic. The final compounds have a larger molecular weight. There are many different wnzymes involved, due to Polymorphism.
4
Q
What are the possible reactions that could occur?
A
Glucuronidation, Sulphation Amino acids Acetylation Methylation
