Amino Acids Flashcards
1
Q
What are three examples of conjugations involving amino acids?
A
Glutathione (GSH)
Glycine
Glutamine
2
Q
What are the three amino acids in the Glutathione conjugation?
A
Glycine
Cystine
Glutamic acid
3
Q
What are the three main groups conjugated in glutathione?
A
Ar-X, Arene oxide, epoxide. There are variations.
4
Q
What is the structure of Glutathione?
A
Tri-peptide structure
5
Q
What is the function of Glutathione (GSH)?
A
At normal doses, GSH conjugates with NAPQI, therefore deactivating it, to prevent the toxicity of NAPQI.
6
Q
What is NQPQI?
A
A Quinone metabolite of Paracetamol that is an oxidative metabolite and is hepatotoxic at high levels.
7
Q
What happens if there is a deficiency in Glutathione?
A
The NAPQI won’t be conjugated, therefore causing toxicity.
