Glucose tolerance lab

Question 1

Where would glucose be found 2 hours after ingestion?

Answer 1

Stored in adipocytes as trigylcerides

Stored in liver and muscle as glycogen

Question 2

How is glucose filtered by the kidney?

Answer 2

Mainly SGLT2 transporters in PCT reabsorbs glucose from lumen into the cell
GLUT-2 transporters moves glucose from cell to bloodstream

Question 3

At what blood glucose concentration would you expect to find glucose in your urine?

Answer 3

11 mmol/l

due to saturation of SGLT2 so glucose can no longer be reabsorbed

Question 4

why is glycosuria not used as a diagnostic marker for diabetes?

Answer 4

because glucose could be in urine for other reasons such as kidney failure

Question 5

when would you find the highest concentration of insulin during a GTT?

Answer 5

After glucose peak

Question 6

when would you find the highest concentration of glucagon during a GTT?

Answer 6

before eating

Question 7

which hormones and neurotransmitters will increase in the procedure of taking blood?

Answer 7

Cortisol (doesn’t affect test because takes time to have an effect)
Adrenaline
Cytokines + inflammatory mediators

Question 8

list the tissues that are totally dependent on glucose as an energy source? explain Why

Answer 8

testes - due to testis blood barrier
Brain - due to BBB
Erythrocytes - no mitochondria

Question 9

why might a patient with diabetes mellitus have glucose >11 moll/l after ran overnight fast?

Answer 9

Due to unopposed glucagon so glucose is released into blood