Gluconeogenesis

Question 1

When pyruvate is transformed to oxaloacetate, what enzyme is used?

Answer 1

Pyruvate carboxylase

*reqs. Biotin and ATP

Question 2

Production of oxaloacetate occurs in

Answer 2

Mitochondria

Question 3

OAA must first be converted to ___ before it can pass the IMM and enter the cytoplasm

Through what enzyme

Answer 3

Malate

Mitochondrial Malate dehydrogenase

Question 4

What enzyme is used to transform malate to OAA?

Answer 4

Cytoplasmic MDH

Question 5

3rd step
OAA is converted to ____ by decarboxylation and phosphorylation

What enzyme is used in this process?

What is used for this phosphorylation step?

Answer 5

Phosphoenol pyruvate

Phospho-Enol-pyruvate carboxy kinase (PEPCK)

GTP

Question 6

Fructose 1,6 bisphosphate is converted to fructose 6-P by what enzyme?

Answer 6

Fructose 1,6 bisphosphatase

Question 7

Fructose 6P is converted to glucose 6P by what enzyme?

Answer 7

Phospho Hexose-Isomerase

Question 8

Glucose 6P is converted to glucose by what enzyme?

Answer 8

Glucose-6 Phosphatase

Question 9

Last step of gluconeogenesis occurs where?

Answer 9

membrane of ER

Question 10

What are the products formed?

Answer 10

Glucose and inorganic phosphate

Question 11

Is the most glucogenic amino acid

Answer 11

Alanine

Question 12

What amino acids are ketogenic?

Answer 12

Leucine
Lysine

Question 13

Amino acids in both ketogenic and glucogenic

Answer 13

Tryptophan, Tyrosine, Threonine
Isoleucine
Phenylalanine

Question 14

TRUE OR FALSE: Fats give more energy than carbohydrates

Answer 14

TRUE