Glucagon

Question 0

Glucagon - MOA (mechanism of action)

Answer 0

Increases blood glucose level by stimulating glycogenesis. Unknown mechanism of stabilizing cardiac rhythm in beta blocker overdose. Minimal positive inotropic and chronotropic response. Decreases GI motility and secretion.

Question 1

Glucagon - Class

Answer 1

Hyperglycemic agent, pancreatic hormone, insulin antagonist.

Question 2

Glucagon - indication

Answer 2

Altered level of consciousness when hypoglycemia is suspected. May be used as inotropic agent in beta blocker overdose.

Question 3

Glucagon - contraindications

Answer 3

Hyperglycemia, hypersensitivity.

Question 4

Glucagon - adverse reactions

Answer 4

Nausea, vomiting, tachycardia, hypertension.

Question 5

Glucagon - Drug interaction

Answer 5

Incompatible in solution with most other substances. No significant drug interactions with other emergency medications.

Question 6

Glucagon - how supplied

Answer 6

1-mg ampules (requires reconstitution with diluent provided)

Question 7

Glucagon - Route

Answer 7

IM

Question 8

Glucagon - dosage and administration

Answer 8

Adult: hypoglycemia: : 0.5-1 mg IM; may repeat in 7-10 min.
Pediatric: hypoglycemia: 0.5-1 mg IM (for children < 20 kg).

Question 9

Glucagon - duration of action

Answer 9

Onset: 1 minute. Peak effect 30 minutes. Duration: variable (generally 9-17 minutes)

Question 10

Glucagon - special considerations

Answer 10

Pregnancy safety: category C. Ineffective if glycogen stores depleted. Should always be used in conjunction with 50% dextrose whenever possible. If patient does not respond to a second dose of glucagon, 50% dextrose must be administered.