Epinephrine

Question 0

Epinephrine - MOA (mechanism of action)

Answer 0

Direct-acting alpha-and beta-agonist. Alpha vasoconstriction. Beta-1 positive inotropic, chronotropic, and dromotropic effects. Beta-2 bronchial smooth muscles relaxation and dilation of skeletal vasculature.

Question 1

Epinephrine - Class

Answer 1

Sympathomimetic

Question 2

Epinephrine - indication

Answer 2

Allergic reaction, anaphylaxis, asthma

Question 3

Epinephrine - contraindications

Answer 3

Hypertension, hypothermia, pulmonary edema, myocardial ischemia, hypovolemic shock.

Question 4

Epinephrine - adverse reaction

Answer 4

Hypertension, tachycardia, arrhythmias, pulmonary edema, anxiety, restlessness, psychomotor agitation, nausea, headache, angina.

Question 5

Epinephrine - drug interactions

Answer 5

Potentiates other Sympathomimetic, MAOIs may potentiate effects, beta blockers may blunt effects.

Question 6

Epinephrine - how supplied

Answer 6

1:1000 solution: ampules and vials containing 1mg/ml. 1:10,000 solution: profiled syringes containing 1mg in 10mL (0.1 ihnnnnnnnnnnnghgggg. Nbbnnbbnb hgJj

Question 7

Epinephrine - route

Answer 7

IM, SC

Question 8

Epinephrine - dosage and administration

Answer 8

Adult: Mild allergic reactions and asthma: 0.3-0.5 mg (0.3-0.5 mL of 1:1000) SC. Anaphylaxis: 0.1 mg (1 mL of 1:10000) IV/IO over 5 min.
Pediatric: Mild allergic reactions and asthma: 0.01 mg/kg (0.01 mL/kg) of 1:1000 solution SC. (Maximum of 0.3 mL)

Question 9

Epinephrine - duration of action

Answer 9

Onset: immediate. Peak: minutes. Duration: several minutes.

Question 10

Epinephrine - special considerations

Answer 10

Pregnancy safety: category C. May cause syncope in asthmatic children. May increase myocardial oxygen demand.