Glomerular perfusion Flashcards
Define renal corpuscle?
Glomerular tuft and Bowmans capsule
Define glomerular tuft?
Convoluted, interconnected glomerular capillaries that protruding into Bowman’s capsule
Where is renal curpuscle?
Kidney
What cells present in renal corpuscle?
Mesangial cells- specialised pericytes
Where are mesangial cells found?
Renal corpuscle
State 4 functions of renal corpuscle?
1) Structural support for capillary
2) Production of extracellular matrix protein
3) Contraction; regulates flow and filtration
tubuloglomerular feedback
4) Phagocytosis of breakdown products
What is bowmans capsule?
What is continuous with it?
Encase glomerulus
Proximal convoluted tubule
What is total glomerular SA?
1m2
Are membranes fenestrated or unfenestrated?
Negative or positive charge?
Fenestrated
Negative charged
Where does filtrate collect?
Bowmans space
What are 2 layers in Bowmans capsule?
Basement membrane
Parietal epithelium cells
What are 3 layers of glomerulus?
Endothelial cells
Basement membrane
Podocytes
What is layer adjacent to capillaries?
Adapted?
Endothelial cells
Fenestrated
Single cell
What sites on top endothelial?
Basement membrane
Fusion 2 bm
Capillary and podocyte BM
Negative charged
What sits on top BM?
Podocytes
Single cell
Foot processes- act filtrate barrier