Filtration Flashcards
Define glomerular filtration rate? (GFR)
Passage of fluid from the blood into Bowman’s space
State 6 factors that determine glomerular filtration rate?
1) Pressure gradients
2) Size of the molecule
3) Charge of the molecule
4) Rate of blood flow
5) Surface area; directly proportional to membrane permeability and surface area
6) Binding to plasma proteins e.g. Ca2+, hormones, fatty acids
What is GFR value?
125ml/min
What does 125ml/min represent?
GFR
What percentage of plasma passes through glomerulus?
20%
State GFR formula?
GFR = (UrineM x urine flow rate) / PlasmaM
M= conc x volume
How to calculate M in fluid? (creatine)
Concentration x Volume
Why is measuring GFR used in clinical settings?
Disease cause loss nephrons
GFR fall
What is used calculate GFR?
Why?
Creatine
Freely filtered by glomerulus but not secreted or absorbed in tubules and not metabolised
What is function of creatine in diagnostic tests?
Why?
Used estimate GFR
Freely filtered by glomerulus
Not secreted/absorbed in tubules
Not metabolised
Define myogenic autoregulation?
Smooth muscle contraction in response to external stretching force, occurs in capillary walls, passive mechanism
If increased NaCl conc what will occur to afferent arteriole?
Constrict
If decreased conc NaCl what will occur afferent arteriole?
Dilation
What causes fast response in arterioles?
GFR
What causes slow response in arterioles?
RAAS
State value normal GFR?
in 24 hrs?
125ml/min
180L in 24 hrs
How much of GFR is reabsorbed?
99%
What is total plasma volume?
IF? Transcellular?
3L
IF- 2 Transcellular- 1
How many times in 24hrs is plasma volume filtered?
60 times/day