Glomerular Diseases

Question 1

What is the compostiton of GBM?

Answer 1

Collagen type 4 and heparan sulfate

Question 2

Layers of GBM?

Answer 2

Lamina densa
Lamina rara interna
Lamina rara externa

Question 3

What type of cells are adherent to lamina rara externa?

Answer 3

Podocytes i.e Visceral epithelial cells

Question 4

What are mesangial cells?

Answer 4

Mesangial cells lie between the capillaries and support the entire glomeular tuft

Question 5

Classify glomerular diseases on histological basis

Answer 5

Hypercellularity
Basement membrane thickening
Hyalinization
Sclerosis

Question 6

Classification of Glomerular diseases

Answer 6

Mnemonic FM3 on AIR
F ~> Focal segmental glomerulosclerosis
M ~> Minimal change disease
M ~> Membranous glomerulopathy
M ~> Membranoproliferative glomerulonephritis
A ~> Acute proliferative glomerulonephritis
I ~> IgA nephropathy
R ~> Rapidly progressive glomerulonephritis

Question 7

Classification of secondary glomerulopathies

Answer 7

Diabetes mellitus ( most common)
SLE
Goodpasture syndrom
Amyloidosis
Wegener granulomatosis
Henoch-Schonlein purpura
Bacterial endocarditis

Question 8

Glomerular diseases
Hereditary disorders classification

Answer 8

Alport syndrome
Thin basement membrane disease
Fabry disease

Question 9

Pathogenesis of Glomerular diseases

Answer 9

May have one of the following pathogenesis
(1) Immune complex mechanism
(2)Anti GBM antibody induced mechanism
(3)cytokine mediated mechanism

Question 10

Immune complex mechanism characterized by what type of deposits?

Answer 10

Granular deposits

Question 11

Anti GBM antibody induce mechanism characterized by what type of deposits?

Answer 11

Linear deposits