Glaucoma Meds

Question 1

PG Analogs

Answer 1

• *First Line**
• Reduces IOP 25-33%
• MOA: increases outflow, considered a “prodrug”
• Warning: binds w melanin, changes iris color
• ADR: increases eyelash growth (“Latisse”), HVS activation, Macular Edema

Question 2

List 3 PG Analogs

Answer 2

1. Latanoprost
2. Travoprost
3. Bimatoprost

Question 3

Alpha Agonists

Answer 3

• Second Line*
• Reduces IOP 20-25%
• MOA: Improves aqueous humor outflow
• ADR: Injection, Hyperemia
• Contraindicated for patients taking anti depressant MAOIs

Question 4

Beta Blockers

Answer 4

(Beta-adrenergic antagonists)

• Reduces IOP 20-25%
• MOA: Decreases aqueous humor production

Question 5

List 3 Beta Blockers

Answer 5

1. Betaxolol (beta-1 specific)
2. Timolol
3. Carteolol

Question 6

List 3 Alpha Agonists

Answer 6

1. Apraclonidine (1st generation)
2. Brimonidine (2nd gen)
3. Brimonidine + Timolol (Combigan)

Question 7

Carbonic Anhydrase Inhibitors (Oral + Topical)

Answer 7

• Reduces IOP by 15-20%
• MOA: Diuretic, decreases aqueous humor secretion by forming bicarb ions
• generally only used if patients don’t do well w other drugs*

Question 8

Which drug is the first line for OA glaucoma, and considered a prodrug?

Answer 8

Prostaglandin Analogs

Question 9

Which drug causes iris hyperpigmentation and eyelash growth>

Answer 9

Prostaglandin Analogs, particularly Latanoprost

Question 10

Which glaucoma drugs decrease aqueous humor production?

Answer 10

1. Carbonic Anhydrase Inhibitors

2. Beta Blockers (Timolol)

Question 11

Which glaucoma drugs increase outflow of aqueous humor?

Answer 11

1. PG Analogs (Latanoprost)

2. Alpha Agonists (Brimonidine)