GIT Disorder

Question 1

GIT Disorder

Answer 1

Peptic Ulcer
Constipation
Diarrhea
Vomiting

Question 2

Eliminate H.Pylori(2 type)

Answer 2

Clarethromycin
Amoxicillin
Tetracycline
Metronidazole

Question 3

Drug used to inhibit Acid secretion

Answer 3

Proton Pump Inhibitor(PPI)
H2 antagonist
Antacid

Question 4

Omeprazole(Prilosec)

Answer 4

Proton Pump Inhibitor(PPI)
Oral with enteric coating
Short T1/2, long action, 24hour to make new enzyme
Absorbed in intestine, via blood to parietal cell, inhibit PP

Question 5

Uses of PPI

Answer 5

Gastric & Duodenal ulcer
Erosive Esophagitis Hyperacidity of stomach
GERD(Gastro Esophageal Reflux Disease)
Hypersecretary state
Dyspepsia

Question 6

H2 antagonist indication

Answer 6

Same as PPI

Also used for stress ulcer

Question 7

H2 antagonist Side fx

Answer 7

Headache, GI upset, Fatigue

CNS effect

Question 8

Camitidine (Tagamet) 400mg/tablet

Answer 8

High adr rx including P450
Gynecomastia(male), Galactorrhea(female) Antiandrogenic fx
Inhibit drug interaction in liver
H2 antagonist

Question 9

Common use H2 antagonist

Answer 9

Ramitidine (Zantac) 150mg/tablet
Fomitidine 200mg/tablet
Nizatidine

Question 10

Common antacid

Answer 10

Magnesium Hydroxide Mg(OH)2 diarrhea
Aluminium Hydroxide Al(OH)3 constip
Sodium Bicarbonate NaHCO3
Calcium Carbonate CaCO3

Question 11

Antacid Used in

Answer 11

Healing peptic ulcer
Relieve symptom of acid ingestion, heart-burn, dyspepsia,
GERD
Prevent stress ulcer, GI bleeding, Hyperphosphatemia in
kidney failure

Question 12

Prostaglandin analogue

Answer 12

Increase blood flow, mucus secretion, bicarbonate secretion,
inhibit acid secretion
Diarrhea
Prevent ulcer secondary to NSAID
Mesoprostol(Oral)(Cytotec)

Question 13

Mucus Protective layer

Answer 13

Sucralfate(oral)(Carafate)(Sucrose, Aluminium)
In present of acid, converted to gill/ glue like material
Need high acidity(empty sto, no antacid)
side fx- constipation,
drug interaction(tetracyclin, ciprofloxacin), interfere acid base balance

Question 14

Anti-diarrhea

Answer 14

Antimotility
Anticholonergic drug
opiod/meperidine analogues
Adsorbent drug(Pectin, Kaolin)

Question 15

Opiod/meperidine analogues

acute

Answer 15

Loperamide(Imodium)-chronic
Diphenoxylate hydrochloride(Lomitil)
Codeine-resistance, addict

Question 16

Type of laxative

Answer 16

Bulk forming agent
Saline & sugar osmotic laxatives
Stimulant or “contact” cathartics
Stool-wetting agents(surfactants/lubricant) & emollients

Question 17

Bulk forming agent

Answer 17

Methylcellulose(Citrucel)
Polycarbophil(Fiberall)
Psyllium Hydrophillic Muciloid(Metamucil)

Question 18

Saline & sugar osmotic laxatives

Answer 18

Lactalluse(oral)-hepatic failure
Polyethylene Glycol(PEG)/ GoLytely-surgery
Saline compound(oral & rectal)

Question 19

Stimulant or “contact” cathartics

Answer 19

Bisacodyl(Dulcolax)
Cascara Sagrada
Castor Oil
Senna (Senokot)

Question 20

Stool-wetting agents(surfactants/lubricant) & emollients

Answer 20

emollient; Calcium, potassium, Sodium salts of docusate

Lubricant - Mineral oil

Question 21

Anti-Emitting drug

Answer 21

Serotonin 5HT3 antagonist(Ondansetron)
Dopamine D2 antagonist(Metoclopramide)
Anticholinergic(Scopolamine)
H1 Antihistaminic(Cyclizine)