Antineoplastic

Question 1

Antimetabolites

Answer 1

Inhibit nuclei acid synthesis(purine, pyramidine)
Compete competitively
Reduce DNA , RNA

Question 2

Methotrexate

Answer 2

Antimetabolite
Antifolate(inhibit DHF Reductase 2»4)
Resistance, high dose(10x), folinic acid resque
Pneumonia, Nephrotoxicity
Acute, Chronic Ca, Breast lung, Psoriasis, Rhematoid Athritis

Question 3

Alkylating Agent

Answer 3

CnH2n+1, Transfer alky group to DNA in n7 of guanine

Breakage of DNA Strand or cross linkage, block DNA synthesis

Question 4

Cyclophosphamide

Answer 4

Alkylating Agent, Prodrug, metabolized by MES
Became Phosphoramide & Acrollin(Haemorrage Cystitis)
Lymphoma, lymphatic leukemia, Ca breast & ovary

Question 5

Acrollin

Answer 5

By product metabolize of cyclophosphamide
Cause haemorrge cystitis,
lowered by high fluid intake
& bladder irrigation
Using N-Acetylcysteine
Or MESNA (Na 2-Metacaptoethane Sulfonate)

Question 6

Hormone

Answer 6

Glucocorticod Prednilosone lymphoma n leukimia
Estrogen in prostate n breast in male
Progestogen in endometrial tumor breast n prostate
Androgen in breast cancer female
Pharma-Tamoxifen
Physiology-Testosterone

Question 7

Cytotoxic Antibiotic

Answer 7

Effect mainly direct to dna
CCNS execpt bleomycin
Free radical generator

Question 8

Doxorubicine

Answer 8

Cytotoxic Antibiotic
Free radical generator Inhibit nuclic acid syntesis
Used in leukemia and lymphomas and solid tomours
Adrs is cardiotixicity( arythemia and CHF)

Question 9

Bleomysin

Answer 9

Cytotoxic Antibiotic
Free radical generator
Use in squamous cell carcinoma, testis n hodgkins
disease(lymphoma)
Adrs pulmonary fibrosis n pnumonia

Question 10

Mitotic spindle poison

Answer 10

Microtubule inhibitors
Inhibit metaphase by binding to tubulin
Used in acute lymphoma leukemia and sarcoma and willms tumor

Question 11

Vesicant.

Answer 11

Adrs locallise tissue damage, thrombophlebitis, parasthesia,

muscle weakness, neuromuscular effect

Question 12

Vincristine and vinblastine

Answer 12

Mitotic spindle poison

From vinca alkalloids , periwinkle plants

Question 13

Aim of chemotheraphy

Answer 13

Curative- Hodgkin’s lymphoma
Palliative - In allevation of sign & symptom
Reduce intensity of manifestation
Dysphagia
Adjuvant - Addition to surgery or radiation to completely eliminate remote micro metastasis

Question 14

General Adr AN

Answer 14

Nausea & vomiting
Bone marrow & lymphoreticular system depression
Damage to GIT lining & mucosa surface
Hair bulb damage
Delayed wound healing
Fx on germ cell
Various organ damage
Secondary cancer
Hyperuricemia
Local toxicity

Question 15

Alternative treatment cancer

Answer 15

Surgical excision
Irridiation
Chemotheraphy

Question 16

Chemotheraphy treatment type

Answer 16

Adjuvent treatment-Used as supplement to reduce number. After
Neo-adjuvant treatment-Before surgery reduce no
Maintainance theraphy-Lower dose in prolonging remission

Question 17

Cancer Characteristic

Answer 17

Uncontrolled proliferation
Differentiation & loss of function
Invasiveness
Metastasis

Question 18

Chemotheraphy Method

Answer 18

Low dose continuously

Full intermittent

Question 19

AN Drug type

Answer 19

Non specific Affect resting & cycling

Specific Affect cycling