GIT - constipation and diarrhoea Flashcards
Drugs for CONSTIPATION (7)
(BOSS COS)
Bulk-Forming Laxatives - increase water in stools
Osmotic Laxatives - increase water in stools
Stool Surfactant Agents (Softeners) - increase water in stools
Stimulant Laxatives - promote peristalsis/motility
Chloride Channel Activators - promote peristalsis/motility
Opioid Receptor Antagonists - promote peristalsis/motility
Serotonin 5-HT4-Receptor Agonists - promote peristalsis/motility
Bulk forming agents
plant products/ synthetic fibres:
Psyllium
Methylcellulose
Polycarbophil
bulk forming agents MOA
Indigestible, hydrophilic colloids (fiber)
Absorb water and form bulk, emollient gel that distends colon (increases stool mass)
Promotes peristalsis -> get rid of food more easily
Stool Surfactant Agents (Softeners)
Docusate (oral or enema - fluid through rectum)
Glycerin (rectal suppository - solid medication through rectum)
Mineral oil (oral)
Stool Surfactant Agents (Softeners) MOA
Lowers surface tension allowing water and lipids to penetrate
Mineral oil lubricates + retards water absorption from stool - so stools still fluid to be passed out
Stool Surfactant Agents (Softeners) concerns
Aspiration can result in severe lipid pneumonitis
Long-term use can impair absorption of fat soluble vitamins (A, D, E and K)
Osmotic Laxatives
nonabsorbable sugars/salts - sorbitol, lactulose, Mg(OH)2, sodium phosphate polyethylene glycol (PEG)** - balanced with osmotically active sugars -> better choice! avoids significant electrolyte shifts
osmotic laxatives MOA
Osmotically-mediated water movement into bowel increases stool liquidity and volume
Increased volume stimulates peristalsis
High doses can produce bowel evacuation (purgation) within 1 to 3 hours
osmotic laxatives ADR
colonic bacteria act on the introduced sugars -> flatus and abdominal cramps
need to maintain adequate hydration
sodium phosphate: hypernatremia, hypocalcemia, hypokalaemia
may cause cardiac arrhythmias or acute renal failure due to tubular deposition of calcium phosphate
osmotic laxatives (sodium phosphate) contraindications
Should not be used in patients who are frail, elderly, on diuretics, unable to maintain adequate hydration or who have renal insufficiency or cardiac disease
Stimulant Laxatives (Cathartics)
Anthraquinone Derivatives:
Aloe, Senna and Cascara (oral or per rectum)
Diphenylmethane Derivatives:
Bisacodyl (faster bowel movement effect if done through rectum, also can be oral): used for bowel prep before colonoscopy
Stimulant Laxatives MOA
Produce migrating colonic contractions
Colonic electrolyte and fluid secretion
Stimulant Laxatives ADR
chronic use may lead to dependence -> long term use
brown pigmentation of the colon
Chloride Channel Activators drug
Lubiprostone
Chloride Channel Activators MOA
Stimulate type 2 chloride channels (ClC-2) in small intestine
Increases chloride-rich fluid secretions
Stimulates motility and shortens intestinal transit time
Chloride Channel Activators ADR + contraindication
return of constipation after discontinuation of drug
nausea caused by delayed gastric emptying
NO PREGNANCY