GI2 Flashcards
Outer surface of the liver is covered by a capsure called
Glisson’s capsule
Hepatocytes are arranged in hepatic plates
Cell thick
In adult, 1 cell thick
Up to 7 yrs, 2 cell thick
Hepatic plates are separated by
Sinusoidal capillaries
Hepatocytes make up
80% of cell population of the liver
Binucleated cells are common
Lifespan of hepatocytes
5 mos
How do hepatic sinusoids differ from other sinusoids?
They have Sinusoidal Macrophages or Kupffer Cells
Sinusoids are lined by endothelium that is
Fenestrated or discontinuous
Cell lining the sinusoids that store Vitamin A but when is in a pathological state it could turn into collagen/myofibroblast
Stellate cells / Hepatic Lipocyte : Lto
Area between sinusoidal endothelium and hepatic plates
Space of disse or pre-sinusoidal space
Space between connective tissue and hepatocytes
Portal canal
Oval or berry shaped - represents the smallest functional unit of the heptic parenchyma
Liver acinus
Short axis of the h. acinus
Long axis
Imaginary line between two portal vein
Imaginary line between two terminal hepatic venule
Zone that’s first to show changes after bile duct occlusion
Zone 1
Sone prone to fat accumulation, ischemic necrosis
High levels of esterases
Zone 3
Monitor blood flow and content in the biliary tree
Cholangiocytes
Smallest branch of biliary tree where bile is secreted from hepatocytes. Smallest canal formed by apposed grooves in the surface of adjacent hepatocytes
Bile cannaliculus
Bile cannaliculus better demonstrated by
Silver impregnation
From intrahepatic bile ductules —> interlobular bile ducts, lines by hepatocytes
T or F
F. Lined by cholangiocytes.
In gall bladder, deep diverticula of the mucosa that may extend up to muscularis mucosa
Rokitansky Aschoff Sinunses
In cystic duct, these are folds that help maintain patency of cystic duct
Spiral Valve of Heister
During relaxed state the gall bladder’s mucosa is
Has numerous mucosal folds
Lining of GB
Simple columnar
Which cells are reponsible in conc. bile
Lining cells
What drains water that will be reabsorbed in the bile
Loose lamina, lamina propria
One thing to take note about the gall bladder’s mucosa and submucosa
Not present lolza
Exocrine pancreas is made up of what kind of glands
Serosal
Principal regulator of the pancreas
Hormones secretin and CCK secreted by enteroendocrine cells
Stimulates duct cells to secrete large volume of fluid with high HCO3
Secretin
Cause acinar cells to secret their proenzymes
CCK
Stimulates acinar and centroacinar
Parasympathetic
Pancreatic enzymes can be activated even intestinal lumen is not reached. T or f
F.
Salivary Purely serous acini
Parotid glands
Secretory ducts are bartholin and rivinus
Sublingual
Predominantly mucous
Shorter but thicker demilunes
Submandibula
Main secretory duct of parotid
Stensens
Mixed gland predokinanty serous
Submandibular/Whartons
