GI Tract (Exam III) Flashcards
What is the name of the canal that extends from the oral cavity to the anus?
alimentary canal
What are 5 phases of food breakdown?
- ingestion
- fragmentation
- digestion
- absorption
- elimination
____ occurs in the oral cavity, accompanied by _____; resulting in ____ formation
ingestion; fragmentation; bolus
The stomach completes ____ & initiates ____
fragmentation; digestion
Contractions of smooth muscles in GI system:
peristalsis
Peristalsis is under ___ control
autonomic
What do pancreatic and biliary secretions in the duodenum do?
emulsification of fat
Where does emulsification of fat occur?
duodenum
What occurs in the jejunum and ileum?
primary absorption of nutrients
What occurs in the colon?
resorption of water & elimination of waste
The muscular tube of GI tract lined by:
mucus membrane
There are a large number of ____ associated with the GI tract
glands
List 3 glands associated with GI tract
- liver glands
- pancreas glands
- intestinal glands
The liver, pancreas and intestinal glands all have what in common?
All embryological outgrowths of the GI tract
Diffuse lymphoid tissue scattered throughout GI tract:
MALT and GALT
What are the 4 distinct layers of the GI tract:
- mucosa
- submucosa
- muscularis externa
- Adventitia (serosa)
The mucosa has 3 overall functions including:
- protection
- secretion
- absorption
Different types of mucosa are modified for:
diferent functions
The mucosa of the GI tract is subdivided into 3 layers including:
- epithelium
- lamina propria
- muscularis mucosae
The layer of mucosa that has secretory & absorptive function;
epithelium
The ____ layer of the mucosa has different modifications at different levels of the GI tract
epithelium
The layer of mucosa- underlying connective tissue
lamina propria
What are some components of the lamina propria? (4)
- lymphoid nodules
- glands
- blood vessels
- lymphatics
The layer of mucosa- thin layer of smooth muscle
muscularis mucosae
The layer of mucosa that is a boundary between the mucosa and submucosa
muscularis mucosa
What does the muscularis mucosa act as a boundary between?
mucosa & submucosa
There are large numbers of ___ & ____ cells in the lamina propria:
lymphocytes and plasma cells (immune surviellence)
Layer of the gut - loose to dense irregular connective tissue layer beneath the muscularis mucosa:
submucosa
Layer of the gut responsible for supporting mucosa:
submucosa
List the components of submucosa:
Larger blood vessels, nerves and lymphatics
Inner circular and outer longitudinal smooth muscle layers of the gut:
muscularis externa
The muscularis externa may also be called:
muscularis propria
The smooth muscle fibers of the muscularis externa are oriented at:
right angles to one another
The inner circular layer of the muscularis externa (propria) contains fibers:
fibers going circumferential around the gut
The outer longitudinal layer of the muscularis externa contains:
muscle fibers orieneted at right angles to one another
The local contractions that result in mixing of food in the gut:
segmentation
Segmentation occurs both ___ & ____ in either direction
proximally and distally
____ propels food only in the distal direction
peristalsis
Overall effect is like kneading bread dough that results in mixing food with digestive secretions but NOT pushing food down the gut
segmentation
When talking peristalsis, another term we can use to describe the direction that food is pushed is ____ which means ____.
Aborally; away from mouth toward anus
Describe the contractions of peristalsis
forecful an organized
Outer loose connective tissue layer of the gut that contains major nerves, vessels, and adipose tissue
adventitia
The adventitia within the abdominal cavity is referred to as:
serosa or visceral peritoneum
The adventitia in the gut (serosa/ visceral peritoneum) is continuous with:
supporting mesentery
The adventitia of the gut (serosa/visceral peritoneum) is lined by:
simple squamous epithelium (mesothelium)
In other areas, the adventia (serosa/visceral peritoneum) merges with:
retroperitoneal tissue
The smooth and shiny surface of the gut
adventitia (serosa/visceral peritoneum)
The smooth muscle of the gut is controlled by:
autonomic nervous system
The parasympathetic stimulation of the smooth muscle of the gut results in:
excitatory
The sympathetic stimulation of smooth muscle of the gut results in”
inhibitor
The parasympathetic motor nerves synapse with:
ganglia located near the effector organ
In the GI tract, ganglia are located:
within wall of gut (within submucosa and muscularis externa)
Clusters of parasympathetic ganglia within the submucosa:
meissner’s plexus (submucosal plexus)
What type of ganglia comprise meissners plexus?
parasympathetic
Larger clusters of ganglia located between inner circular and outer longitudinal muscular layers:
myenteric or Auerbachs plexus
Short, muscular tube lined by stratified squamous nonkeratinized epithelium
Esophagus
What type of cells line the esophagus?
stratified squamous nonkeratinized epithelium
In the upper third of the esophagus the muscularis externa is composed of:
The middle third of esophagus is composed of:
The lower third of the esophagus is composed of:
voluntary skeletal muscle
Skeletal & smooth muscle
Smooth muscle only
Due to the muscle make up of the esophagus, swallowing occurs in the upper 1/3 made of _____ so it is _____
Vomiting occurs in the Lower 1/3 of the esophagus made of _____ so it is ____
- skeletal muscle; voluntary
- smooth muscle; involuntary
Where is the gastroesophageal sphinctor located?
Gastroesophageal junction between stomach and esophagus
Heart burn:
pyrosis
Pyrosis is due to regurgitation of ____ into the _____ from the ____ of the stomach
stomach acid; distal esophagus; cardia
Regions of the stomach: (3)
cardia; fundus; pyrorus
The carida is surrounded by:
smooth muscle cardiac sphinctor
The smooth muscle cardiac sphinctor that surrounds the cardia is known as the:
gastroesophageal sphinctor
Adjacent to the esophagus; contains predominantly mucus-secreting glands:
cardiac sphincter (gastroesophageal sphinctor)
The glandular portion of the stomach:
fundus
The fundus secretes (3)
acid, pepsin, some mucus
Somes texts differentiate the fundus from the ____. Both are glandular but the fundus is closest to the _____ and the _____ is closest to the ____.
-corups
-cardia
- corpus; pyrloris
Portion of the stomach containing primarily mucus (&gastrin) secreting glands
pylorus
The smooth muscle ____ control outflow from the stomach into duodenum
pylroric sphinctor
The loss of stomach/duodenal epithelium/ mucosa:
peptic/gastric ulcer
An ulcer occurs when damage extends below the level of the _____ leading to bleeding.
basement membrane and lamina propria
Partial loss of the epithelium of the stomach leading to no bleeding
erosion
What is the treatment for peptic/gastric ulcers?
antacids (tagamet, cimetidine)
The term peptic ulcers house:
stomach and duodenal ulcers
Ulcers are frequently assoicated with:
chronic infection w/ helicobacter pylori
Helicobacter pylori produce ____ resulting in _____ and secondarily leading to____
urease; increased gastric pH; increased acid production
Treatment of helicobacter pylori includes:
triple therapy
The triple therapy used to treat helicobacter pylori includes:
2 long term antibiotics & proton pump inhibitor
Distensible organ used for food storage:
stomach
How many chambers does the stomach have in most animals?
one
In the stomach food undergoes mechanical breakdown via ____ and chemical breakdown via ____ to form ____
muscular activity; gastric secretions; chyme
In addition to the inner circular and outer longitudinal layers of the stomach, there is also:
3rd inner oblique layer in muscularis externa
Little _____ occurs in the stomach
What are the exceptions?
absorption
exceptions: water, alcohol, & some drugs
The stomach lining contains prominent longitudinal folds called:
ruggae
In the glandular body of the stomach (fundus), muscosa contains prominent:
gastric pits called foveolae
The gastric pits (foveolae) of the fundus forms the entrance to ____
gastric glands
The gastric glands of the fundus are:
straight tubular glands
The gastric glands of the stomach secrete:
~2 liters of watery gastric juice/ day
The watery gastric juice secreted by the gastric glands of the stomac contains: (what makes up the gastric juice and at what PH)
- HCL (pH~1)
- pepsinogen
Pepsinogen is an _____ of ____.
inactive precurser of pepsin
Pepsinogen is converted to pepsin by the action of:
HCL
In addition to the pepsinogen and HCL, what other components are found in the gastric juices of the stomach?
gastrin, renin, & lipase
How does the mucosa of the stomach protect itself from the harsh environment?
thick layer of mucus
Gastric glands contain how many types of cells? name them
5 classes
- mucus secreting cells
-acid secreting cells
- pepsin secreting cells
- enteroendocrine cells
- undifferentiated stem cells