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GI secretions Flashcards

1
Q

Where is gastrin produced?

A

G cells in stomach

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2
Q

What is the effect of gastrin?

A

Increases stomach motility, growth of gastric mucosa and acid production

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3
Q

What is gastrin stimulated by?

A

Stomach distension, amino acids, vagal

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4
Q

What is gastrin inhibited by?

A

Acidity, somatostatin, CCK, secretin

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5
Q

Where is CCK secreted from?

A

I cells in duodenum and jejunum

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6
Q

What is the action of CCK?

A

Contraction of gall bladder, pancreatic enzyme secretion, inhibits stomach acid

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7
Q

What is CCK stimulated by?

A

Fatty acids and amino acids

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8
Q

What is CCK inhibited by?

A

Trypsin and somatostatin

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9
Q

Where is secretin released from?

A

S cells in duodenum

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10
Q

What is the action of secretin?

A

HCO3- secretion from pancreas, inhibits bile secretion and stomach acid

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11
Q

What is secretin stimulated by?

A

Acidity, fatty acids

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12
Q

Where is somatostatin secreted from?

A

D cells in pancreatic islets and GI mucosa

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13
Q

What is the action of somatostatin?

A

Inhibits stomach acid, pancreatic (enzyme and HCO3-), pepsinogen, CCK, secretin, insulin and glucagon secretions.

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14
Q

What is somatostatin stimulated by?

A

Acidity

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15
Q

What is somatostatin inhibited by?

A

Vagal stimulation (ACh)

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16
Q

Where is vasoactive intestinal polypeptide (VIP) secreted from?

A

Parasympathetic ganglia in sphincters, gall bladder, SI

17
Q

What is VIP’s action?

A

Increases intestinal motility and intestinal fluid secretion

18
Q

What stimulates VIP?

A

Stomach distension, vagal stimulation

19
Q

Where is motilin produced?

A

Small intestine M cells

20
Q

What is the function of motilin?

A

Increases intestinal motility and migrating motor complexes

21
Q

What stimulates motilin?

A

Fasting

22
Q

Where is intrinsic factor secreted from?

A

Parietal cells of the stomach

23
Q

What is the function of intrinsic factor?

A

Cobalamine (B12) uptake in the liver

24
Q

What is secretin inhibited by?

A

Somatostatin

GI (13 decks)

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