GI: pancreas

Question 1

Pancreatitis

• define
• etiology

Answer 1

inflammation of pancreas

• develops bc of obstruction to the outflow of pancreatic digestive enzymes caused by bile and pancreatic duct obstruction
• **obstruction MC gallstone
• **another MC etiology is ETOH
• prematurely activate pancreatic enzymes–autodigestion–

Question 2

causes of acute pancreatitis

Answer 2

ETOH abuse MC

• truama
• idiopathic 2MC
• hypocalcemia
• hyperlipidemia
• iselt cell tumors
• familial
• trauma
• iatrogenic
• gallstones NOT significant as in acute

Question 3

pancreatic exocrine insufficiency
-define
-

Answer 3

-insuff pancreatic enzyme production–lipase, amalyase, trypsin or chymotrypsin

causes:
- pancreatitis
- pacreatic carcinoma
- pancreatic resection
- CF

*fat maldigestion is the main problem–>PT will exhibit fatty stools and weight loss

Question 4

what are some causes of acute pancreatitis that can lead to chronic?

Answer 4

CF 
ETOH 
Trauma 
tumors 
infection--mumps, CMV, 
meds

Question 5

pancreatic CA

-types

Answer 5

1. ductal adenocarcinomas–>pancreatic tumors from metaplastic exocrine cells in the ducts

Causes:

• chronic pancreatitis–>inflamatory cytokines suport tumor growth
• s/s show later on dz

2. Pancreatic Neuroendocrine tumor–ex Insulinomas